Brain Activity, Cognitive Function, and Walking Ability in Parkinson's Disease

Recruiting

• Conditions: Healthy Older Adults; Parkinson Disease
• Interventions: Behavioral: Cognitive function, gait, and electroencephalogram

• Registration Number: NCT06588920
• Lead Sponsor: National Yang Ming Chiao Tung University

Brief Summary

The dual-task automated walking performance in people with Parkinson\'s disease (PD) is affected by their gait disturbances and impaired executive functions. Currently, the relationship between brain activity related to inhibitory control, executive functions, and dual-task walking performance in people with PD is not well understood. Therefore, this study aims to investigate the significance of different executive function domains on gait stability in healthy older adults and people with PD; whether brain activation related to inhibitory control is associated with gait stability in healthy older adults and people with PD.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-09-05
• Study First Submitted QC: 2024-09-05
• Study First Posted: 2024-09-19
• Study Start: 2024-10-09
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-17
• Last Update Posted: 2025-02-19
• Primary Completion: 2027-08-31
• Study Completion: 2027-08-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Diagnoses of idiopathic Parkinson disease
• Stable dopaminergic medicine ≥ 2 weeks
• Able to walk 10 meters without aid
• Mini-Mental Status Examination ≥ 24 points
• No uncorrected visual or auditory disorders
• Education at least junior high school
• No other disease may affect balance

Exclusion Criteria

• Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders
• History of brain surgery (e.g. deep brain stimulation)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Parkinson disease	Cognitive function, gait, and electroencephalogram	People with Parkinson disease
Healthy older adults	Cognitive function, gait, and electroencephalogram	Healthy older adults

Primary Outcome Measures

Name	Time	Method
Gait variability	1 day	Using GAITRite system to measure the coefficient of variation (CV). The mean and standard deviation will be used to calculate the coefficient of variation (CV). CV = standard deviation / mean \* 100%
Gait speed	1 day	Using GAITRite system to measure gait speed.
Step length	1 day	Using GAITRite system to measure step length
Step width	1 day	Using GAITRite system to measure step width.
Single support time	1 day	Using GAITRite system to measure single support time
Double support time	1 day	Using GAITRite system to measure double support time
Frontal Assessment Battery	1 day	The score ranged from 0 to 18. Higher scores show better executive function.
Trail making test	1 day	Trail making test contain part A and part B. Faster completing the test indicates better executive function.
Stroop color and word test	1 day	Record numbers of corrected color words which the subject responds within 45 sec.
Event-related potential - N2	1 day	Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Event-related potential - P300	1 day	Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Digit span test	1 day	Digit span test contain forward and backward part. Scores of forward digit span ranges from 0 to 16. Score of backward digit span ranges from 0 to 14. Higher scores indicate better executive function.
Go/Nogo test	1 day	Behavioral test during measuring electroencephalography.

Trial Locations

Locations (1)

National Yang Ming Chiao Tung University; 🇨🇳 Taipei, Taiwan