Determining the stability of TRECs - an important measure for thymic activity.
Completed
- Conditions
- T cell dynamics during immune suppression10021460TREC stability
- Registration Number
- NL-OMON37746
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
kidney transplantation(s);
longterm (>10 years) immune suppression by mycophenolate mofetil and/or azathioprine
Exclusion Criteria
chronic graft rejection;
thymectomy;
T cell defect(s) prior to transplantation
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The stability (and thereby half-life) of TRECs.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The changes in telomere length of naive T cells in patients treated with the<br /><br>immune suppressives mycophenolate mofetil and/or azathioprine.</p><br>