A Retrospective Cohort Study on Predicting Delayed Graft Function in Liver Transplant Patients with Hepatocellular Carcinoma: a Nomogram and Machine Learning Approaches.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- TBIL/AST/ALT/INR
研究概览
简要总结
Background: This study aimed to develop a predictive model for delayed graft function (DGF) in liver transplant patients with hepatocellular carcinoma (HCC) based on preoperative biochemical indicators, using both logistic regression and XGBoost machine learning algorithms.
Methods: A retrospective cohort study was conducted, including 131 liver transplant patients from January 2020 to April 2022. Preoperative biochemical markers and hematological parameters were analyzed. Logistic regression and XGBoost models were constructed to predict DGF, and their performance was evaluated using the area under the ROC curve (AUC). Shapley Additive Explanations (SHAP) analysis was employed to interpret the feature contributions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Days 至 75 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with liver cancer aged between 18 and 75 years.
- •Patients who have received liver transplantation.
- •Complete preoperative and postoperative medical imaging data, clinical records and pathological test reports are available.
排除标准
- •Primary non-hepatocellular carcinoma
- •Recipients were younger than 18 years and older than 75 years
- •Due to incomplete or missing clinical data, this dataset did not meet the criteria for inclusion in the statistical analysis.
- •Serious complications associated with liver transplantation, such as acute transplant rejection or transplant liver failure, occur within 7 days after surgery.
- •Re-surgery within 7 days after surgery due to liver transplant-related complications or other surgical procedures, such as transplant site infection or other major surgery.
结局指标
主要结局
TBIL/AST/ALT/INR
时间窗: Results of biochemical examination on the 7th day after liver transplantation in patients with hepatocellular carcinoma.
次要结局
未报告次要终点
研究者
Jian You
Research assistant
Wuhan University