Whole Egg Intake and Choline Concentration in the Aging Brain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Association Between Cerebral Choline and Cognition
研究概览
简要总结
By doing this study, researchers hope to learn to see if there is relationship between whole egg consumption and brain choline status. Additionally, researchers also plan to see if there is a relationship between brain choline status and cognition.
详细描述
Participants will come to the research center for 2 different visits. Visit 1 will include anthropometric measurements, surveys, and a cognitive test. Approximately 7-10 days after visit 1, participants will come back to the research center for visit 2. At visit 2, participants will return surveys and a MRI scan will be performed to measure brain choline status. Potential participants need to be located within the Kansas City metro area.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged between 60 - 85 years of age
- •Good general health with no concomitant diseases
- •Cognitively normal as defined as Mini-mental state examination (MMSE) score ≥ 25
- •BMI range: 20 - 40 kg/m2
排除标准
- •Presence of central neurological disease (e.g., brain tumor, stroke, epilepsy, motor neuron disease, multiple sclerosis, Alzheimer's, Parkinson's)
- •Prior major head trauma with loss of consciousness
- •Presence of active unstable and life-threatening illness (e.g., cancer)
- •Presence of major psychiatric disorder within the past 3 years including depression, anxiety, and alcohol (over 3 drinks per day or total of 18 per week) or drug abuse (DSM-IV criteria; Geriatric Depression Score > 6)
- •Presence of diabetes mellitus or use of anti-diabetic agents
- •Use of psychoactive and investigational medications
- •Use of hormone replacement therapy
- •Tobacco smokers
- •Subjects with MRI contraindications
结局指标
主要结局
Association Between Cerebral Choline and Cognition
时间窗: Baseline
The investigators will test the association between cerebral choline as measured by MRS and cognition. Cognition will be measured by the NIH ToolBox cognitive battery.
Association Between Whole Egg Intake and Cerebral Choline
时间窗: Baseline
The investigators will recruit a variety of whole egg consumers. Egg consumption will be validated with a 7-day food record 1 week before the MRI. Cerebral choline levels are measured by magnetic resonance spectroscopy (MRS)
次要结局
未报告次要终点