Whole Egg Intake and Choline Concentration in the Aging Brain
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alzheimer Disease
- Sponsor
- University of Kansas Medical Center
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Association Between Cerebral Choline and Cognition
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
By doing this study, researchers hope to learn to see if there is relationship between whole egg consumption and brain choline status. Additionally, researchers also plan to see if there is a relationship between brain choline status and cognition.
Detailed Description
Participants will come to the research center for 2 different visits. Visit 1 will include anthropometric measurements, surveys, and a cognitive test. Approximately 7-10 days after visit 1, participants will come back to the research center for visit 2. At visit 2, participants will return surveys and a MRI scan will be performed to measure brain choline status. Potential participants need to be located within the Kansas City metro area.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Aged between 60 - 85 years of age
- •Good general health with no concomitant diseases
- •Cognitively normal as defined as Mini-mental state examination (MMSE) score ≥ 25
- •BMI range: 20 - 40 kg/m2
Exclusion Criteria
- •Presence of central neurological disease (e.g., brain tumor, stroke, epilepsy, motor neuron disease, multiple sclerosis, Alzheimer's, Parkinson's)
- •Prior major head trauma with loss of consciousness
- •Presence of active unstable and life-threatening illness (e.g., cancer)
- •Presence of major psychiatric disorder within the past 3 years including depression, anxiety, and alcohol (over 3 drinks per day or total of 18 per week) or drug abuse (DSM-IV criteria; Geriatric Depression Score \> 6)
- •Presence of diabetes mellitus or use of anti-diabetic agents
- •Use of psychoactive and investigational medications
- •Use of hormone replacement therapy
- •Tobacco smokers
- •Subjects with MRI contraindications
Outcomes
Primary Outcomes
Association Between Cerebral Choline and Cognition
Time Frame: Baseline
The investigators will test the association between cerebral choline as measured by MRS and cognition. Cognition will be measured by the NIH ToolBox cognitive battery.
Association Between Whole Egg Intake and Cerebral Choline
Time Frame: Baseline
The investigators will recruit a variety of whole egg consumers. Egg consumption will be validated with a 7-day food record 1 week before the MRI. Cerebral choline levels are measured by magnetic resonance spectroscopy (MRS)