Improving Outcomes In Diabetic Patients During CABG Surgery By Optimizing Glycemic Control
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- glycemic control
研究概览
简要总结
This study seeks to determine whether varying the dose of insulin and glucose in diabetic patients during coronary bypass surgery will improve outcomes in these patients.
详细描述
Our previous study has shown that maintaining serum glucose between 120-180mg/dl in the perioperative period during CABG surgery in diabetic patients improves outcomes. The purpose of this trial is: (1) to determine whether outcomes can be improved by altering the content of glucose or insulin in these solutions (2)to determine the effect of these solutions and glycemic control on the inflammatory response of arterial and venous conduits used during surgery, (3) to determine whether the beneficial effects of improved glycemic control can be correlated with changes in the inflammatory response.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diabetic CABG patients
排除标准
- •Renal and hepatic failure
研究组 & 干预措施
B Low dose GIK
This group will have low doses of glucose and insulin
干预措施: B Low Dose GIK (Drug)
C High Dose GIK
This group will have high doses of insulin and glucose
干预措施: C High Dose GIK (Drug)
A Insulin
This group will receive only an intravenous insulin infusion
干预措施: A IV Insulin drip (Drug)
结局指标
主要结局
glycemic control
时间窗: 24 hours following surgery
glycemic control, postoperative morbidity, inflammatory markers
时间窗: 24 hours following surgery
次要结局
- free fatty acid levels(24 hours following surgery)
研究者
Harold L. Lazar MD
Professor of Cardiothoracic Surgery
American Heart Association