Effects of Intraoperative Local Steroid Utilization in a Single-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion
Overview
- Phase
- Phase 3
- Intervention
- Dexamethasone
- Conditions
- Dysphasia
- Sponsor
- Rush University Medical Center
- Enrollment
- 105
- Primary Endpoint
- Postoperative Pain
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The purpose of this study is to determine if the frequency and duration of postoperative pain are improved in participants receiving a local steroid injection (methylprednisolone) plus a systemic (intravenous (IV, by vein)) steroid (dexamethasone) when compared to those receiving a systemic (IV) steroid (dexamethasone) alone. Both of these steroid injections are already currently used at Rush and are considered standard of practice. It is well established that steroids have an anti-inflammatory (decreased swelling) effect on the soft tissue and it is routinely used in many types of surgery, but it is not known whether two steroids are better than one. The medications provided in this study are approved by the Food and Drug Administration (FDA).
Detailed Description
Postoperative pain is a well-known complication following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). It has been found that up to 40% of lumbar spinal patients will have either recurrent or persistent postoperative pain. Several studies have demonstrated reduced patient reported pain scores following steroid administration. However, few studies have investigated intraoperative local injection of corticosteroid at the surgical site in an effort to reduce the incidence and duration of postoperative pain for MIS TLIF patients. The purpose of this study is to determine if the incidence and duration of postoperative pain is improved in participants receiving a local injection of methylprednisolone with systemic dexamethasone when compared to those receiving the usual systemic dexamethasone undergoing MIS TLIF. The investigators hypothesize that participants undergoing MIS TLIF who receive local methylprednisolone along with the systemic dexamethasone will have: 1. Reduced incidence and duration of postoperative pain compared to participants receiving only systemic dexamethasone. 2. Shorter hospital stay compared to participants receiving only systemic dexamethasone. 3. Better short- and long-term outcomes compared to participants receiving only systemic dexamethasone
Investigators
Kern Singh
Professor, Department of Orthopaedic Surgery
Rush University Medical Center
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing a primary 1- to 2-level MIS TLIF
- •Diagnosis: myelopathy, radiculopathy, myeloradiculopathy, stenosis, herniated nucleus pulposus, degenerative disc disease, spondylosis, osteophytic complexes, and foraminal stenosis
- •Patients able to provide informed consent
Exclusion Criteria
- •Allergies or other contraindications to medicines in the protocol including:
- •(a) Existing history of gastrointestinal bleeding
- •Current Smokers
- •Lumbar spine trauma
- •Bilateral cages
- •Lack of consent
Arms & Interventions
IV dexamethasone
Standard systemic (IV) dexamethasone only
Intervention: Dexamethasone
Local Depomedrol plus IV dexamethasone
Local intraoperative application of methylprednisolone (Depomedrol) plus standard systemic (IV) dexamethasone
Intervention: Methylprednisolone
Local Depomedrol plus IV dexamethasone
Local intraoperative application of methylprednisolone (Depomedrol) plus standard systemic (IV) dexamethasone
Intervention: Dexamethasone
Outcomes
Primary Outcomes
Postoperative Pain
Time Frame: 2 years postoperative
Change in Visual Analogue Scale Back and Leg score from preoperative value will be assessed
Secondary Outcomes
- Physical Functioning(2 years postoperative)
- Disability(2 years postoperative)
- General health status(2 years postoperative)
- Narcotic Consumption(1 week postoperative)
- Length of Stay(1 week postoperative)
- Intra-operative adverse events(day of surgery)
- Post-operative adverse events(1 week postoperative)