Permissive Hypercapnia, Alveolar Recruitment and Limited Airway Pressures reduce injury in Acute Respiratory Distress Syndrome.
Phase 2
Completed
- Conditions
- Acute respiratory distress syndrome.Respiratory - Other respiratory disorders / diseases
- Registration Number
- ACTRN12607000465459
- Lead Sponsor
- Intensive Care Unit, Alfred Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
(1) Diagnosis of Acute Respiratory Distress Syndrome based on the American-European Consensus Conference criteria.
Exclusion Criteria
Patients were excluded if they had chest trauma, an intercostal catheter with air
leak, a pneumothorax on chest x-ray, bronchospasm on auscultation, raised intracranial pressure, mean arterial pressure less than or equal to 60 mmHg, significant arrhythmias or were
ventilated for longer than 72 hours.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma pro-inflammatory cytokine levels (IL-6). [Days 0 (twice), 1, 3, 5 and 7. ]
- Secondary Outcome Measures
Name Time Method Plasma pro-inflammatory cytokine levels (TNF-a, IL-1B, IL-8)[Day 0 (twice),1 ,3 ,5 and 7.];Length of mechanical ventilation and hospital mortality. [Length of mechanical ventilation censored at 28 days and hospital survival will be recorded. ];PaO2/FiO2 ratios and static lung compliance. These are derived from clinical respiratory measurements including arterial blood gases, ventilation settings, peak and plateau pressure, tidal volume and PEEP.[At baseline, 1, 3, 6 and 24 hours and then daily during the period of mechanical ventilation<br>up to seven days.];ICU length of stay through recording of ICU admission and discharge date/time. [ICU length of stay will be recorded. ];Hospital length of stay through recording of Hospital admission and discharge date/time. [Hospital length of stay will be recorded. ]