Mycoplasma Genitalium Infection and Associated Antimicrobial Resistance Among HIV-infected Male in Hong Kong
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 573
- 试验地点
- 1
- 主要终点
- prevalence of MG infection
研究概览
简要总结
Worldwide, Mycoplasma genitalium (MG) is increasingly reported as an emerging cause of sexually transmitted infections. Internationally, the prevalence of MG is higher in male with urethritis and community groups especially among people living with HIV (PLHIV). While MG is treatable, antimicrobial resistance is a rising concern. This cross-sectional study aims to determine the prevalence of MG infection and the antimicrobial resistance pattern in HIV-infected male in Hong Kong.
A total of 750 HIV-infected male attending HIV specialist clinic in Hong Kong would be recruited. The main outcome measures include prevalence of MG and resistance mutations to macrolide/fluoroquinolone in HIV-infected male; prevalence of MG/STI co-infections, as defined by concurrent detection of MG and one or more other bacterial STI.
详细描述
A total of 750 HIV-infected male attending HIV specialist clinic in Hong Kong would be recruited. An online questionnaire would be self-administered. The participants would self-collect urine sample, rectal and pharyngeal swabs for MG, Chlamydia trachomatis (CT) and Neisseria Gonorrhoeae (NG) screening by nucleic acid amplification tests, and MG genotypic resistance mutations detection. Clinical data would be transcribed from medical records of recruited subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •aged 18 or older, male, HIV-infected, and are attendees of the HIV specialist clinic, and can communicate in written and spoken English or Chinese
排除标准
- •not able to provide consent
结局指标
主要结局
prevalence of MG infection
时间窗: 1 year
detection of MG infections in self-collected samples divided by the total number of samples collected
prevalence of MG resistance mutations
时间窗: 1 year
* detection of MG resistance mutations macrolide/fluoroquinolone in MG positive samples divided by the total number of MG positive samples * detection of MG resistance mutations macrolide/fluoroquinolone in MG positive samples divided by the total number of samples collected
次要结局
- prevalence of overall STI(1 year)
- prevalence of CT infection(1 year)
- prevalence of NG infection(1 year)
- prevalence of syphilis(1 year)
- prevalence of HCV infection(1 year)
研究者
Ngai Sze WONG
Assistant Professor
Chinese University of Hong Kong