Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 122
- 试验地点
- 1
- 主要终点
- Diagnostic Accuracy of the changes in serum creatinine for volemic classification of hyponatremia
研究概览
简要总结
Retrospective study that analyzes the changes in serum creatinine as a tool to correctly classify the volemic status volemic status (euvolemia vs hypovolemia) of the patients with hyponatremia.
详细描述
This study evaluates the usefulness of the changes in serum creatinine in differentiating between euvolemia and hypovolemia in hyponatremic patients. Changes in serum creatinine were retrospectively analyzed . The latter was calculated subtracting the serum creatinine value of eunatremia from that of hyponatremia, and was categorized as an increase when it was "positive", or "decrease/no change" when it was negative or equal to zero. The percentual change in serum creatinine was also calculated.
Two groups of patients were selected for the current study. First group was conformed by patients with hypovolemic hyponatremia, and second group by patients with euvolemic hyponatremia. Data from eunatremia as well as the hyponatremic episode were collected. Both groups were matched in Receiver operating characteristic curve analyzes where both arithmetical and percentual changes in serum creatinine were assessed and cut-off points were selected for an additional Odd Ratio analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with hypovolemic hyponatremia secondary to any cause
- •Patients with euvolemic hyponatremia caused by Syndrome of inappropriate antidiuresis
- •Complete clinical volemia assessment during hyponatremia.
- •Presence of serum creatinine measured in eunatremia as well as in hyponatremic episodes.
排除标准
- •Pregnants.
- •Patients with a prior history of diabetes, advanced chronic kidney disease (glomerular filtrate rate below 30 ml/min), cirrhosis, or heart failure were excluded.
- •Patients with hypervolemic hyponatremia.
结局指标
主要结局
Diagnostic Accuracy of the changes in serum creatinine for volemic classification of hyponatremia
时间窗: 4 months
Area under the curve from the Receiver operating characteristic curve analysis were calculated for the changes in serum creatinine. Probabilities of each evaluated tool (arithmetic and percentual change in serum creatinine) to correctly classified the volemic status of the hyponatremic patients were calculated.
次要结局
- Ratio of Correct volemic classification of hyponatremia when Changes in Serum creatinine were used.(4 months)
- Diagnostic Accuracy of Urine sodium for volemic classification of hyponatremia(4 months)
研究者
Jorge Gabriel Ruiz Sánchez
Principal investigator
Hospital San Carlos, Madrid