Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma

Recruiting

• Conditions: Diffuse Intrinsic Pontine Glioma; Brainstem Glioma

• Registration Number: NCT01106794
• Lead Sponsor: Children's National Research Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-4-19
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Inclusion Criteria:<br><br> - Patients of any age with clinical and radiologic diagnosis of diffuse intrinsic<br> pontine glioma<br><br> - Patients with other high-grade gliomas originating in the brainstem<br><br> - Patients with focal gliomas (WHO grade I/II) of the brainstem<br><br>Exclusion Criteria:<br><br> - Patients with any type of infiltrative low grade (WHO grade I and II) or high grade<br> glioma (WHO grade III and IV) originating outside the brainstem<br><br> - Patients harboring primary brainstem tumors with other histologic diagnoses (e.g.,<br> PNET)

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Genome-wide expression patterns of RNA in tumor samples, normal brainstem tissue and cerebrospinal fluid using Affymetrix gene expression profiling;Validation of results of the genome-wide analysis;Proteomic profiling of tumor, normal brainstem tissue and cerebrospinal fluid;Protein expression patterns as assessed by immunohistochemistry and western blot compared to normal brainstem tissue;Genome-wide analysis of tumor samples and normal brainstem tissue;In vitro and in vivo molecular analysis of collected samples

Secondary Outcome Measures

Name	Time	Method
Assess aspects associated with specimen acquisition, including potential benefits and drawbacks