NCT00448604已完成不适用
Impact of Viral Infections in Patients With Chronic Obstructive Pulmonary Diseases: Virological Work-up During Exacerbations and 1-year Follow-up
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 86
- 试验地点
- 1
研究概览
简要总结
The objectives of the study are
- to determine the prevalence of respiratory virus infections in COPD patients, during and outside acute exacerbation
- to explore the impact of these viral infections on the outcome of these patients
- to explore the association between blood procalcitonin levels and viral infections in this population.
详细描述
Background
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity due to repeated exacerbations. The impact of viral infections during and outside COPD exacerbations is poorly understood and there is only scarce data on the role of new biological markers of infection for the management of COPD exacerbations.
Objectives of the project
The investigators aim to
- describe the epidemiology of viral infections in patients admitted with an exacerbation of their COPD;
- explore the evolution of viral infections outside exacerbations;
- analyze the impact of viral infections on clinical outcomes;
- explore the role of biological markers (CRP, procalcitonin) for the diagnosis and prognosis of viral infections.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All consecutive patients known or suspected for moderate to very severe COPD and admitted in the emergency center for an acute exacerbation of their COPD
- •Age above 18 years
- •We plan to include 100 patients with a complete work-up and follow-up
- •Written informed consent will be obtained from every participant
排除标准
- •Patients requiring oro-tracheal intubation
- •Patients unable to give their informed consent due to their clinical condition
- •Other obvious cause of dyspnea (pulmonary embolism, acute pulmonary edema, lobar pneumonia)
- •Patients suffering from bronchiectasis, asthma, pulmonary fibrosis and mineral dust pneumoconiosis
- •Patients with a history of active tuberculosis
- •Patients with a history of ischemic cerebral stroke and subsequent deglutition dysfunction
研究者
研究点 (1)
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