ACTRN12621001738819
Recruiting
未知
A multicentre randomised controlled trial evaluating whether a computed tomography calcium score in women with non-traditional cardiovascular risk factors can detect premature atherosclerosis and be used to improve cardiovascular risk factor control
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- cardiovascular disease
- Sponsor
- The University of Sydney
- Enrollment
- 700
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Women able to give their informed consent will be eligible for inclusion if they are:
- •Criteria 1: Aged 40\-65 years (35\-65 years if Aboriginal and Torres Strait Islander)
- •Criteria 2: Low or intermediate risk for CVD based on traditional risk score (Australian absolute cardiovascular risk score between 3\-15% inclusive)
- •Criteria 3: At least 1 risk\-enhancing factor(s) (‘novel’ CVD risk factor) of:
- •a.Hypertensive disorder of pregnancy: gestational hypertension or pre\-eclampsia and/or
- •b.Gestational diabetes and/or
- •c.Premature menopause (surgical/natural of age 44 years and less) and/or
- •d.Aboriginal and/or Torres Strait Islander background
Exclusion Criteria
- •Very low risk for CVD (3% or below) or high risk for CVD (\>15%) based on an Australian Absolute cardiovascular disease risk calculator: https://www.cvdcheck.org.au
- •Age 60 or over with diabetes mellitus (this automatically equates to risk score \>15%)
- •Pre\-existing cardiovascular disease (cardiac, cerebrovascular or peripheral vascular disease)
- •Known statin intolerance
- •On dialysis (as this can affect calcium scoring)
- •Currently pregnant or breastfeeding or plans for future pregnancies
- •Limited life expectancy of more than 5 years or diagnosis with a terminal illness
- •Unable to provide informed consent
Outcomes
Primary Outcomes
Not specified
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