Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage

Recruiting

• Conditions: Obesity; Inflammation

• Registration Number: NCT04275674
• Lead Sponsor: National Cheng-Kung University Hospital

Brief Summary

The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation. Obesity is associated with an increased risk of recurrent miscarriage (RM), but the underlying mechanisms are unclear. Abnormal inflammasome activation was also identified in the endometrium of women who experienced RM. Given inflammasome activation has emerged as common pathophysiology in obesity-related disorder and RM, the investigators wonder whether inflammasome activation occurs in the uterine macrophages of obese women, and result in early reproductive failure.

Detailed Description

pending

Study Timeline

• Study Start: 2017-08-01
• Study First Submitted: 2019-10-28
• Study First Submitted QC: 2020-02-17
• Study First Posted: 2020-02-19
• Status Verified: 2022-09
• Last Update Submitted: 2022-10-03
• Last Update Posted: 2022-10-04
• Primary Completion: 2023-07
• Study Completion: 2023-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 57

Inclusion Criteria

All women have conceived naturally without the aid of assisted reproductive technologies

Exclusion Criteria

N/A

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Validity of inflammatory markers	1 Day	Use the levels of hsCRP and CA125 provides the information about inflammation.

Trial Locations

Locations (1)

National Cheng-Kung University Hospital; 🇨🇳 Tainan, Taiwan