Clinical trial to evaluate the effect of face Serum in Mukhadushika Prepared by the combination Of Vata, Lodhra and Manjishta.

Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous unit which is characterized by the formation of non-inflammatory open and closed comedones & inflammatory papules, pustules, nodules, and cysts. Acne vulgaris is a common skin disease affecting more than 85% of adolescents and two-thirds of adults aged 18 years and older. The four main pathogenetic factors that contribute to acne are follicular hyperkeratinization, increased sebum production, Propionibacterium acnes (P. acnes) inside the follicle, and inflammation.. Acne vulgaris can be correlated with mukhadushika based on the symptom, a disease mentioned in kshudraroga. Presently various treatment modalities are adopted for acne which includes anti-inflammatory, antibiotics, and comedolytic agents. However, they are reported to be expensive and with many adverse effects. Lepa works well to treat acne. Practically lepa is difficult to prepare and apply due to stain, smell, fluidity, non-availability of fresh herbs also lack of time. In the present era, there is a demand for potent, easily applicable quick formulations that are in terms of patient convenience, affordability, and less side effects. Face serums have higher concentrations of key ingredients. Properties such as light skincare formulation, thinner in viscosity, and low-density aid in rapid absorption and deeper penetration. Face serum market growing at a compound annual growth rate (CAGR) of 4.8% from 2022 to 2031 Face serum are easy to apply, carry and store.

AIMS AND OBJECTIVES OF THE STUDY AIMS - To evaluate the effect of face serum, prepared by the combination of Vata, Lodra and Manjishta in mukhadushika. OBJECTIVES – 1.Preparation of water-based face serum & analysis of its physicochemical characteristics & phytochemicals 2. To evaluate the clinical efficacy of face serum in acne vulgaris