Investigation of Docosahexaenoic Acid (DHA) Metabolic Pathway in Human by Using 13C Labeled Molecules

Not Applicable

Completed

• Conditions: Healthy Subject
• Interventions: Drug: 13-C labeled AceDoPC-DHA; Drug: 13-C labeled TG-DHA; Drug: 13-C labeled PC-DHA

• Registration Number: NCT02168738
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

The purpose of this study is to compare three lipidic forms of DHA in their metabolic pathway in human by using 13C labeled molecules.

The circulating form of DHA plays a major role in his cerebral incorporation. The aim of this research is to confirm that some lipidic forms are best carriers for the cerebral incorporation in studying 13C-DHA distribution in plasma lipids and blood cells.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03
• Study First Submitted: 2014-03-21
• Study First Submitted QC: 2014-06-19
• Study First Posted: 2014-06-20
• Primary Completion: 2015-04
• Study Completion: 2015-04
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-26
• Last Update Posted: 2016-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 4

Inclusion Criteria

• Healthy male
• Aged of 60 to 70 years
• Body Mass Index of 20 to 30 kg/m2
• Glycaemic and lipid parameters normal

Exclusion Criteria

• Smokers more than ten cigarettes/day
• Medical history of personal or family dyslipidemia
• Medication that could interfere with lipid metabolism

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
13-C labeled PC-DHA	13-C labeled AceDoPC-DHA	-
13-C labeled PC-DHA	13-C labeled TG-DHA	-
13-C labeled PC-DHA	13-C labeled PC-DHA	-
13-C labeled TG-DHA	13-C labeled AceDoPC-DHA	-
13-C labeled TG-DHA	13-C labeled TG-DHA	-
13-C labeled TG-DHA	13-C labeled PC-DHA	-
13-C labeled AceDoPC-DHA	13-C labeled AceDoPC-DHA	-
13-C labeled AceDoPC-DHA	13-C labeled TG-DHA	-
13-C labeled AceDoPC-DHA	13-C labeled PC-DHA	-

Primary Outcome Measures

Name	Time	Method
Concentration of 13C-DHA in red blood cells	At Day 1	6 hours after product ingestion

Secondary Outcome Measures

Name	Time	Method
Concentration of 13C-DHA in plasma lipids	At Day 1	6 hours after product ingestion
Concentration of 13C-DHA in platelets	At Day 1	6 hours after product ingestion

Trial Locations

Locations (1)

Centre de Recherche en Nutrition Humaine Rhône-Alpes, 165 chemin du Grand Revoyet,; 🇫🇷 Pierre Benite, France