MedPath

Pazopanib Hydrochloride in Treating Patients With Progressive Carcinoid Tumors

Phase 2
Active, not recruiting
Conditions
Foregut Neuroendocrine Tumor
Hindgut Neuroendocrine Tumor
Metastatic Digestive System Neuroendocrine Tumor G1
Metastatic Neuroendocrine Tumor
Midgut Neuroendocrine Tumor G1
Neuroendocrine Tumor G2
Recurrent Digestive System Neuroendocrine Tumor G1
Regional Digestive System Neuroendocrine Tumor G1
Interventions
Procedure: Biospecimen Collection
Procedure: Computed Tomography
Procedure: Echocardiography
Other: Laboratory Biomarker Analysis
Procedure: Magnetic Resonance Imaging
Procedure: Multigated Acquisition Scan
Other: Placebo Administration
Other: Quality-of-Life Assessment
Procedure: X-Ray Imaging
Registration Number
NCT01841736
Lead Sponsor
National Cancer Institute (NCI)
Brief Summary

This randomized phase II trial studies how well pazopanib hydrochloride works in treating patients with carcinoid tumors that are growing, spreading, or getting worse. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Detailed Description

PRIMARY OBJECTIVE:

I. For patients with progressive carcinoid tumors, progression-free survival (PFS defined by central review according to Response Evaluation Criteria in Solid Tumors \[RECIST\] 1.1) will be compared between patients randomized to treatment with pazopanib (pazopanib hydrochloride) versus placebo.

SECONDARY OBJECTIVES:

I. Overall survival (OS) will be compared between treatment arms. II. Objective response rate, duration of response, and time to treatment failure will be compared between treatment arms.

III. Progression free survival (PFS) as assessed by central radiology review and local radiology review will be compared overall and within treatment arms.

IV. Safety and tolerability of treatment with pazopanib/placebo will be evaluated within each treatment arm.

V. PFS and other indicators of efficacy will be estimated in patients who crossover to pazopanib from placebo.

VI. To determine the turn-around time for timely adjudicated central review. VII. To characterize the nature of discordance between local and central radiology review in assessment of progression.

VIII. To characterize the type and rate of progression in carcinoid (at study entry, on-study, and at progression).

IX. To develop new methods for modeling carcinoid growth and detecting treatment effects, and to perform simulations that advance new clinical trial designs to apply to future trials of carcinoid therapeutics.

X. To assess for differences in quality of life (QOL)-related domains between the two treatment groups (pazopanib versus placebo).

XI. To determine if the more brief measures of QOL-related domains provide comparable information to that which is provided by the longer assessments (European Organization for Research and Treatment of Cancer \[EORTC\], neuroendocrine tumors \[NET\]21).

XII. To provide validation data for the EORTC NET21 module in terms of responsiveness over time and differences across arms.

XIII. To determine whether components of the plasma angiome panel that have been shown to be predictive previously (interleukin-6 \[IL-6\] and vascular endothelial growth factor \[VEGF\]-D) are predictive of a therapeutic advantage for pazopanib treatment in baseline samples from the patients treated on A021202.

XIV. To determine whether other components of the plasma angiome panel tested (not IL-6 and VEGF-D) are predictive of a therapeutic advantage for pazopanib treatment in baseline samples from the patients treated on A021202.

XV. To evaluate the changes in the plasma angiome markers after treatment with or without pazopanib over time.

EXPLORATORY OBJECTIVES:

I. PFS at 6 months will be estimated within each treatment arm. II. Biochemical response (for chromogranin A, defined as a decrease of 50% or more in chromogranin A levels from baseline and for 5-hydroxyindoleacetic acid \[5-HIAA\], defined as a decrease of 50% or more in urinary 5-HIAA levels from baseline) will be compared between treatment arms among patients with elevated baseline levels of chromogranin A (CGA) and 5-HIAA.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive pazopanib hydrochloride orally (PO) once daily (QD) on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo echocardiography (ECHO) or multigated acquisition scan (MUGA) during screening. Patients also undergo computed tomography (CT), magnetic resonance imaging (MRI), and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.

ARM II: Patients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.

After completion of study treatment, patients are followed up every 3-6 months for 5 years.

Recruitment & Eligibility

Status
ACTIVE_NOT_RECRUITING
Sex
All
Target Recruitment
171
Inclusion Criteria
  • Low- or intermediate-grade neuroendocrine carcinoma, including the following subtypes: carcinoid tumor, low- to intermediate-grade or well- to moderately-differentiated neuroendocrine carcinoma or tumor, atypical carcinoid tumor; documentation from a primary tumor or metastatic site is sufficient; patients with poorly differentiated neuroendocrine carcinoma, high-grade neuroendocrine carcinoma, adenocarcinoid tumor, or goblet cell carcinoid tumor are not eligible

  • Locally unresectable or metastatic carcinoid tumors

  • Patients must have histologic documentation or clinical evidence of a carcinoid tumor of primary site (including foregut, midgut, hindgut or other non-pancreatic site); tumors of unknown primary site are eligible provided the treating physician does not suspect medullary thyroid cancer, pancreatic neuroendocrine tumor, paraganglioma, or pheochromocytoma; unknown primary tumors will be classified as small bowel tumors for the purpose of stratification; functional (associated with a clinical syndrome) or nonfunctional tumors are allowed; target lesions must have shown disease progression if therapy included peptide receptor radiotherapy (PRRT) and PRRT must be completed at least 8 weeks prior to registration

  • Radiological evidence for progressive disease (measurable or non-measurable) within 12 months prior to registration; patients who have received anti-tumor therapy during the past 12 months (including octreotide analogs) must have had radiological documentation of progression of disease while on or after receiving therapy

  • No known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage; patients with lesions infiltrating major pulmonary vessels (contiguous tumor and vessels) are excluded; however, the presence of a tumor that is touching, but not infiltrating (abutting) the vessels is acceptable (computed tomography [CT] with contrast is strongly recommended to evaluate such lesions); patients with large protruding endobronchial lesions in the main or lobar bronchi are excluded; however, endobronchial lesions in the segmented bronchi are allowed

  • Patients must have measurable disease per RECIST 1.1 by computed tomography (CT) scan or magnetic resonance imaging (MRI); lesions must be accurately measured in at least one dimension (longest diameter to be recorded) as >= 1 cm with CT or MRI (or >= 1.5 cm for lymph nodes); index lesions for the purpose of RECIST 1.1 measurements will not be selected from within the radiation therapy treatment field; however, if there is evidence of disease progression within the radiation treatment field, measurement of the progressing lesions will be documented

  • No prior treatment with an inhibitor of vascular endothelial growth factor (VEGF) or vascular endothelial growth factor receptor (VEGFR)

  • Prior treatment (somatostatin analogs excepted) must be completed at least 2 weeks prior to registration; in addition, prior treatment (somatostatin analogs excepted) must be completed at least 4 weeks prior to initiation of study drug; treatment-related toxicities must have improved to =< grade 1 prior to registration, with the exception of alopecia

  • Concurrent use of somatostatin analogs (SSTa) is allowed, provided that the patient is on a stable dose for at least two months and progressive disease on somatostatin analog has been documented; progression on octreotide is required for patients with tumors arising in the midgut

  • Prior treatment with embolization (including bland embolization, chemoembolization, and selective internal radiation therapy) or ablative therapies is allowed if measurable disease remains outside of the treated area or there is documented disease progression in a treated site; there is no limit on the prior number of procedures; prior liver-directed or other ablative treatment must be completed at least 8 weeks prior to registration; index lesions for the purpose of RECIST 1.1 measurements will not be selected from within the radiation therapy treatment field; however, if there is evidence of disease progression within the radiation treatment field, measurement of the progressing lesions will be documented

  • Patients should have completed any major surgery >= 4 weeks prior to registration and must have completed any minor surgery >= 2 weeks prior to registration; patients must have fully recovered from the procedure

    • The following are examples of procedures considered to be minor: port placement, laparoscopy, thoracoscopy, bronchoscopy, mediastinoscopy, skin biopsies, incisional biopsies, imaging-guided biopsy for diagnostic purposes, and dental extraction procedures
    • Insertion of a vascular access device, thoracentesis, paracentesis, and endoscopic ultrasonographic procedures are not considered to be major or minor surgeries
  • No concurrent condition resulting in immune compromise, including chronic treatment with corticosteroids or other immunosuppressive agents

  • No clinical evidence of central nervous system (CNS) metastases (including carcinomatous meningitis) at baseline, with the exception of those patients who have previously-treated CNS metastases (surgery +/- radiotherapy, radiosurgery, or gamma knife) and who meet both of the following criteria: a) are asymptomatic and b) had no requirement for steroids or enzyme-inducing anticonvulsants within 6 months prior to registration

  • No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 28 days prior to registration

  • No clinically significant gastrointestinal abnormalities that may increase the risk for gastrointestinal bleeding within 28 days prior to registration including, but not limited to:

    • Active peptic ulcer
    • Known endoluminal metastatic lesion(s) with history of bleeding
    • Inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease), or other gastrointestinal conditions with increased risk of perforation
  • No history of serious (i.e., requiring active medical therapy with medication or medical device under the supervision of a physician) non-healing wound, ulcer, trauma, or bone fracture within 28 days prior to study entry

  • Patients with a history of hypertension must have blood pressure that is adequately controlled on antihypertensives; (< 140/90 mm Hg)

  • No symptomatic congestive heart failure (New York Heart Association class II, III, or IV) within 6 months prior to registration

  • No arterial thrombotic events within 6 months of registration, including transient ischemic attack (TIA), cerebrovascular accident (CVA), peripheral arterial thrombus, myocardial infarction (MI), or unstable angina or angina requiring surgical or medical intervention in 6 months prior to registration; patients with clinically significant peripheral artery disease (i.e., claudication on less than one block) are ineligible; patients who have experienced a deep venous thrombosis or pulmonary embolus within 6 months prior to registration must be on stable therapeutic anticoagulation for at least 6 weeks prior to enrollment of this study

  • Patients on therapeutic anticoagulation with low molecular weight heparins, fondaparinux, rivaroxaban or warfarin are eligible, provided that they are on a stable dose of anticoagulants; patients who are currently receiving antiplatelet therapy of prasugrel or clopidogrel or antiaggregation agents (e.g., eptifibatide, epoprostenol, dipyridamole) or low doses of acetylsalicylic acid (up to 100 mg daily) are also eligible

  • No ongoing cardiac dysrhythmias, atrial fibrillation, or prolongation of corrected QT (QTc) interval to > 480 msec

  • No evidence of active bleeding, bleeding diathesis, or hemoptysis (>= 1/2 teaspoon of red blood) within 8 weeks prior to registration

  • No currently unstable angina and/or uncontrolled cardiac arrhythmias

  • Patients with symptomatic peripheral vascular disease are ineligible

  • Ejection fraction on echocardiogram (Echo) or multi gated acquisition scan (MUGA) > 50%

  • Chronic concomitant treatment with strong inhibitors of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) is not allowed on this trial; patients on strong CYP3A4 inhibitors must discontinue the drug 14 days prior to the start of study treatment

  • Women must not be pregnant or nursing; women of child bearing potential must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin [HCG]) within 72 hours prior to registration; women of child-bearing potential include any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy, bilateral tubal ligation or bilateral oophorectomy) or is not postmenopausal (defined as amenorrhea >= 12 consecutive months; or women on hormone replacement therapy [HRT] with documented serum follicle stimulating hormone [FSH] level > 35 mIU/mL)

  • Age >= 18 years of age

  • Eastern Cooperative Oncology Group (ECOG) performance status 0-1

  • Granulocytes >= 1,500/mcL

  • Platelets >= 100,000/mcL

  • International normalized ratio (INR) =< 1.2 X upper limit of normal (ULN); only required for patients receiving anticoagulant therapy; patients are eligible if their INR is stable and within the recommended range for the desired level of anticoagulation

  • QTc =< 480 msecs

  • Thyroid stimulating hormone (TSH) within normal limits (WNL); medications for thyroid dysfunction are allowed as long as TSH is normal at registration; in patients with abnormal TSH, if the free thyroxine (free T4) and free thyroxine index (FTI) are normal and patient is clinically euthyroid, patient is eligible

  • Bilirubin =< 1.5 x ULN

  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) & alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x ULN; concomitant elevations in bilirubin and AST/ALT above 1.0 X ULN are NOT permitted; also, if liver metastases are present, AST & ALT =< 5 x ULN is allowed

  • Serum creatinine =< 1.5 x ULN

  • Urine protein to creatinine ratio < 1, or, 24-hour urine protein < 1 g; if urine protein to creatinine (UPC) >= 1, then a 24-hour urine protein must be assessed; patients must have a 24-hour urine protein value < 1 g to be eligible; use of urine dipstick for renal function assessment is not acceptable

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Arm && Interventions
GroupInterventionDescription
Arm I (pazopanib hydrochloride)Pazopanib HydrochloridePatients receive pazopanib hydrochloride PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm I (pazopanib hydrochloride)Biospecimen CollectionPatients receive pazopanib hydrochloride PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm I (pazopanib hydrochloride)Computed TomographyPatients receive pazopanib hydrochloride PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm I (pazopanib hydrochloride)EchocardiographyPatients receive pazopanib hydrochloride PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm I (pazopanib hydrochloride)Laboratory Biomarker AnalysisPatients receive pazopanib hydrochloride PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm I (pazopanib hydrochloride)Magnetic Resonance ImagingPatients receive pazopanib hydrochloride PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm I (pazopanib hydrochloride)Multigated Acquisition ScanPatients receive pazopanib hydrochloride PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm I (pazopanib hydrochloride)Quality-of-Life AssessmentPatients receive pazopanib hydrochloride PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm I (pazopanib hydrochloride)X-Ray ImagingPatients receive pazopanib hydrochloride PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm II (placebo)Biospecimen CollectionPatients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm II (placebo)Computed TomographyPatients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm II (placebo)EchocardiographyPatients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm II (placebo)Laboratory Biomarker AnalysisPatients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm II (placebo)Magnetic Resonance ImagingPatients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm II (placebo)Multigated Acquisition ScanPatients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm II (placebo)Placebo AdministrationPatients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm II (placebo)Quality-of-Life AssessmentPatients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Arm II (placebo)X-Ray ImagingPatients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. At the time of progressive disease, patients may cross-over to Arm I. Patients undergo ECHO or MUGA during screening. Patients also undergo CT, MRI, and chest x-ray throughout the trial. Patients may optionally undergo blood sample collection during screening and on study.
Primary Outcome Measures
NameTimeMethod
Progression-free Survival (PFS)From date of patient entry until documented progression of disease or death from any cause, assessed up to 5 years

PFS will be measured from date of patient entry until documented progression of disease as determined by central review or death from any cause. If a patient does not have a documented date of progression or death, then PFS will be censored at the date of last adequate assessment. PFS will be estimated within treatment arm using the Kaplan-Meier method. Progression is defined as any new lesion or increase by ≥20% of previously involved sites from nadir based on RECIST criteria.

Secondary Outcome Measures
NameTimeMethod
Best ResponseUp to 5 years

The best response per RECIST 1.1 criteria of participants receiving randomized treatment assignment. Complete response (CR): Disappearance of all evidence of disease, Partial response (PR): Regression of measurable disease and no new sites, Stable disease (SD): Neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD taking as references the smallest sum diameters while on study. Progressive disease (PD): Any new lesion or increase by ≥20% of previously involved sites from nadir. Note that those considered evaluable for best response here were those who had disease measurements while on treatment. Those who discontinued therapy early prior to a disease evaluation were not included.

Overall SurvivalFrom randomization until death from any cause, assessed up to 5 years

Overall survival (OS) will be measured from randomization until death from any cause. A patient who is alive at the time of the statistical analysis will be considered censored at the last date of known contact. OS will be estimated by the Kaplan-Meier method within each treatment arm.

Duration of Response for the Subset of Patients With a Confirmed Complete Response or Partial ResponseFrom first documented evidence of complete response or partial response until first documented disease progression or death from any cause, assessed up to 5 years

Duration of response is defined as the time from documented response to time of progression and/or death. This time-to-event outcome will be summarized descriptively using the methods of Kaplan and Meier to characterize the cohort and distribution of this outcome.

Time to Treatment FailureFrom randomization until termination of protocol therapy for any reason including progression of disease, adverse events, and death, assessed up to 5 years

Time to treatment failure is defined as the time from randomization to the time that treatment is terminated, including the reasons of disease progression, adverse events, withdrawal from study, or death. This time-to-event outcome will be evaluated using the methods of Kaplan and Meier.

Time to Second Progression for Patients Who Crossover From Placebo to Active TherapyUp to 5 years

Trial Locations

Locations (427)

Alaska Breast Care and Surgery LLC

🇺🇸

Anchorage, Alaska, United States

Alaska Women's Cancer Care

🇺🇸

Anchorage, Alaska, United States

Anchorage Oncology Centre

🇺🇸

Anchorage, Alaska, United States

Katmai Oncology Group

🇺🇸

Anchorage, Alaska, United States

Providence Alaska Medical Center

🇺🇸

Anchorage, Alaska, United States

Mayo Clinic in Arizona

🇺🇸

Scottsdale, Arizona, United States

Kaiser Permanente-Anaheim

🇺🇸

Anaheim, California, United States

Kaiser Permanente-Baldwin Park

🇺🇸

Baldwin Park, California, United States

Kaiser Permanente-Fontana

🇺🇸

Fontana, California, United States

Kaiser Permanente South Bay

🇺🇸

Harbor City, California, United States

Kaiser Permanente-Irvine

🇺🇸

Irvine, California, United States

Kaiser Permanente Los Angeles Medical Center

🇺🇸

Los Angeles, California, United States

Los Angeles General Medical Center

🇺🇸

Los Angeles, California, United States

USC / Norris Comprehensive Cancer Center

🇺🇸

Los Angeles, California, United States

Kaiser Permanente West Los Angeles

🇺🇸

Los Angeles, California, United States

Cedars Sinai Medical Center

🇺🇸

Los Angeles, California, United States

Palo Alto Medical Foundation Health Care

🇺🇸

Palo Alto, California, United States

Stanford Cancer Institute Palo Alto

🇺🇸

Palo Alto, California, United States

Kaiser Permanente - Panorama City

🇺🇸

Panorama City, California, United States

Kaiser Permanente-Riverside

🇺🇸

Riverside, California, United States

Kaiser Permanente-San Diego Mission

🇺🇸

San Diego, California, United States

Kaiser Permanente-San Diego Zion

🇺🇸

San Diego, California, United States

UCSF Medical Center-Mount Zion

🇺🇸

San Francisco, California, United States

UCSF Medical Center-Mission Bay

🇺🇸

San Francisco, California, United States

Kaiser Permanente-San Marcos

🇺🇸

San Marcos, California, United States

Palo Alto Medical Foundation-Santa Cruz

🇺🇸

Santa Cruz, California, United States

Palo Alto Medical Foundation-Sunnyvale

🇺🇸

Sunnyvale, California, United States

Kaiser Permanente-Woodland Hills

🇺🇸

Woodland Hills, California, United States

The Medical Center of Aurora

🇺🇸

Aurora, Colorado, United States

Boulder Community Hospital

🇺🇸

Boulder, Colorado, United States

Rocky Mountain Cancer Centers-Boulder

🇺🇸

Boulder, Colorado, United States

Penrose-Saint Francis Healthcare

🇺🇸

Colorado Springs, Colorado, United States

Rocky Mountain Cancer Centers-Penrose

🇺🇸

Colorado Springs, Colorado, United States

AdventHealth Porter

🇺🇸

Denver, Colorado, United States

Colorado Blood Cancer Institute

🇺🇸

Denver, Colorado, United States

Presbyterian - Saint Lukes Medical Center - Health One

🇺🇸

Denver, Colorado, United States

Rocky Mountain Cancer Centers-Midtown

🇺🇸

Denver, Colorado, United States

Saint Joseph Hospital - Cancer Centers of Colorado

🇺🇸

Denver, Colorado, United States

Rocky Mountain Cancer Centers-Rose

🇺🇸

Denver, Colorado, United States

Rose Medical Center

🇺🇸

Denver, Colorado, United States

Western States Cancer Research NCORP

🇺🇸

Denver, Colorado, United States

Mercy Medical Center

🇺🇸

Durango, Colorado, United States

Mountain Blue Cancer Care Center - Swedish

🇺🇸

Englewood, Colorado, United States

Swedish Medical Center

🇺🇸

Englewood, Colorado, United States

Poudre Valley Hospital

🇺🇸

Fort Collins, Colorado, United States

Mountain Blue Cancer Care Center

🇺🇸

Golden, Colorado, United States

Banner North Colorado Medical Center

🇺🇸

Greeley, Colorado, United States

Rocky Mountain Cancer Centers-Greenwood Village

🇺🇸

Greenwood Village, Colorado, United States

Rocky Mountain Cancer Centers-Lakewood

🇺🇸

Lakewood, Colorado, United States

Saint Anthony Hospital

🇺🇸

Lakewood, Colorado, United States

AdventHealth Littleton

🇺🇸

Littleton, Colorado, United States

Rocky Mountain Cancer Centers-Sky Ridge

🇺🇸

Lone Tree, Colorado, United States

Sky Ridge Medical Center

🇺🇸

Lone Tree, Colorado, United States

Longmont United Hospital

🇺🇸

Longmont, Colorado, United States

Rocky Mountain Cancer Centers-Longmont

🇺🇸

Longmont, Colorado, United States

Banner McKee Medical Center

🇺🇸

Loveland, Colorado, United States

AdventHealth Parker

🇺🇸

Parker, Colorado, United States

Rocky Mountain Cancer Centers-Parker

🇺🇸

Parker, Colorado, United States

Saint Mary Corwin Medical Center

🇺🇸

Pueblo, Colorado, United States

Rocky Mountain Cancer Centers - Pueblo

🇺🇸

Pueblo, Colorado, United States

Intermountain Health Lutheran Hospital

🇺🇸

Wheat Ridge, Colorado, United States

Smilow Cancer Hospital Care Center at Saint Francis

🇺🇸

Hartford, Connecticut, United States

Beebe Medical Center

🇺🇸

Lewes, Delaware, United States

Delaware Clinical and Laboratory Physicians PA

🇺🇸

Newark, Delaware, United States

Helen F Graham Cancer Center

🇺🇸

Newark, Delaware, United States

Medical Oncology Hematology Consultants PA

🇺🇸

Newark, Delaware, United States

Christiana Care Health System-Christiana Hospital

🇺🇸

Newark, Delaware, United States

Beebe Health Campus

🇺🇸

Rehoboth Beach, Delaware, United States

TidalHealth Nanticoke / Allen Cancer Center

🇺🇸

Seaford, Delaware, United States

Christiana Care Health System-Wilmington Hospital

🇺🇸

Wilmington, Delaware, United States

Moffitt Cancer Center

🇺🇸

Tampa, Florida, United States

John B Amos Cancer Center

🇺🇸

Columbus, Georgia, United States

Memorial Health University Medical Center

🇺🇸

Savannah, Georgia, United States

Pali Momi Medical Center

🇺🇸

'Aiea, Hawaii, United States

Queen's Cancer Center - Pearlridge

🇺🇸

'Aiea, Hawaii, United States

Hawaii Cancer Care Inc - Waterfront Plaza

🇺🇸

Honolulu, Hawaii, United States

Queen's Medical Center

🇺🇸

Honolulu, Hawaii, United States

Straub Clinic and Hospital

🇺🇸

Honolulu, Hawaii, United States

University of Hawaii Cancer Center

🇺🇸

Honolulu, Hawaii, United States

Hawaii Cancer Care Inc-Liliha

🇺🇸

Honolulu, Hawaii, United States

Queen's Cancer Center - Kuakini

🇺🇸

Honolulu, Hawaii, United States

Kapiolani Medical Center for Women and Children

🇺🇸

Honolulu, Hawaii, United States

Castle Medical Center

🇺🇸

Kailua, Hawaii, United States

Wilcox Memorial Hospital and Kauai Medical Clinic

🇺🇸

Lihue, Hawaii, United States

Saint Alphonsus Cancer Care Center-Boise

🇺🇸

Boise, Idaho, United States

Kootenai Clinic Cancer Services - Post Falls

🇺🇸

Post Falls, Idaho, United States

Illinois CancerCare-Carthage

🇺🇸

Carthage, Illinois, United States

Illinois CancerCare-Bloomington

🇺🇸

Bloomington, Illinois, United States

Illinois CancerCare-Canton

🇺🇸

Canton, Illinois, United States

Northwestern University

🇺🇸

Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center

🇺🇸

Chicago, Illinois, United States

Cancer Care Specialists of Illinois - Decatur

🇺🇸

Decatur, Illinois, United States

Decatur Memorial Hospital

🇺🇸

Decatur, Illinois, United States

Illinois CancerCare-Eureka

🇺🇸

Eureka, Illinois, United States

Illinois CancerCare-Galesburg

🇺🇸

Galesburg, Illinois, United States

Ingalls Memorial Hospital

🇺🇸

Harvey, Illinois, United States

Illinois CancerCare-Kewanee Clinic

🇺🇸

Kewanee, Illinois, United States

Illinois CancerCare-Macomb

🇺🇸

Macomb, Illinois, United States

Loyola University Medical Center

🇺🇸

Maywood, Illinois, United States

SSM Health Good Samaritan

🇺🇸

Mount Vernon, Illinois, United States

Illinois CancerCare-Ottawa Clinic

🇺🇸

Ottawa, Illinois, United States

Illinois CancerCare-Pekin

🇺🇸

Pekin, Illinois, United States

Illinois CancerCare-Peoria

🇺🇸

Peoria, Illinois, United States

Illinois CancerCare-Peru

🇺🇸

Peru, Illinois, United States

Illinois CancerCare-Princeton

🇺🇸

Princeton, Illinois, United States

Elkhart Clinic

🇺🇸

Elkhart, Indiana, United States

Michiana Hematology Oncology PC-Elkhart

🇺🇸

Elkhart, Indiana, United States

Elkhart General Hospital

🇺🇸

Elkhart, Indiana, United States

Indiana University/Melvin and Bren Simon Cancer Center

🇺🇸

Indianapolis, Indiana, United States

Community Howard Regional Health

🇺🇸

Kokomo, Indiana, United States

IU Health La Porte Hospital

🇺🇸

La Porte, Indiana, United States

Michiana Hematology Oncology PC-Mishawaka

🇺🇸

Mishawaka, Indiana, United States

Saint Joseph Regional Medical Center-Mishawaka

🇺🇸

Mishawaka, Indiana, United States

Michiana Hematology Oncology PC-Plymouth

🇺🇸

Plymouth, Indiana, United States

Reid Health

🇺🇸

Richmond, Indiana, United States

Newman Regional Health

🇺🇸

Emporia, Kansas, United States

Memorial Hospital of South Bend

🇺🇸

South Bend, Indiana, United States

South Bend Clinic

🇺🇸

South Bend, Indiana, United States

Northern Indiana Cancer Research Consortium

🇺🇸

South Bend, Indiana, United States

Michiana Hematology Oncology PC-Westville

🇺🇸

Westville, Indiana, United States

Mary Greeley Medical Center

🇺🇸

Ames, Iowa, United States

McFarland Clinic - Ames

🇺🇸

Ames, Iowa, United States

University of Iowa Healthcare Cancer Services Quad Cities

🇺🇸

Bettendorf, Iowa, United States

McFarland Clinic - Boone

🇺🇸

Boone, Iowa, United States

Mercy Hospital

🇺🇸

Coon Rapids, Minnesota, United States

Oncology Associates at Mercy Medical Center

🇺🇸

Cedar Rapids, Iowa, United States

Mercy Cancer Center-West Lakes

🇺🇸

Clive, Iowa, United States

UI Health Care Mission Cancer and Blood - West Des Moines Clinic

🇺🇸

Clive, Iowa, United States

Iowa Methodist Medical Center

🇺🇸

Des Moines, Iowa, United States

Iowa-Wide Oncology Research Coalition NCORP

🇺🇸

Des Moines, Iowa, United States

UI Health Care Mission Cancer and Blood - Des Moines Clinic

🇺🇸

Des Moines, Iowa, United States

Mercy Medical Center - Des Moines

🇺🇸

Des Moines, Iowa, United States

UI Health Care Mission Cancer and Blood - Laurel Clinic

🇺🇸

Des Moines, Iowa, United States

Iowa Lutheran Hospital

🇺🇸

Des Moines, Iowa, United States

University of Iowa/Holden Comprehensive Cancer Center

🇺🇸

Iowa City, Iowa, United States

McFarland Clinic - Jefferson

🇺🇸

Jefferson, Iowa, United States

McFarland Clinic - Marshalltown

🇺🇸

Marshalltown, Iowa, United States

Siouxland Regional Cancer Center

🇺🇸

Sioux City, Iowa, United States

Mercy Medical Center-Sioux City

🇺🇸

Sioux City, Iowa, United States

Saint Luke's Regional Medical Center

🇺🇸

Sioux City, Iowa, United States

Methodist West Hospital

🇺🇸

West Des Moines, Iowa, United States

Mercy Medical Center-West Lakes

🇺🇸

West Des Moines, Iowa, United States

Saint Catherine Hospital

🇺🇸

Garden City, Kansas, United States

Saint Rose Ambulatory and Surgery Center

🇺🇸

Great Bend, Kansas, United States

HaysMed

🇺🇸

Hays, Kansas, United States

University of Kansas Cancer Center-West

🇺🇸

Kansas City, Kansas, United States

University of Kansas Cancer Center

🇺🇸

Kansas City, Kansas, United States

The University of Kansas Cancer Center - Olathe

🇺🇸

Olathe, Kansas, United States

Menorah Medical Center

🇺🇸

Overland Park, Kansas, United States

University of Kansas Cancer Center-Overland Park

🇺🇸

Overland Park, Kansas, United States

Saint Luke's South Hospital

🇺🇸

Overland Park, Kansas, United States

Mercy Hospital Pittsburg

🇺🇸

Pittsburg, Kansas, United States

Kansas City NCI Community Oncology Research Program

🇺🇸

Prairie Village, Kansas, United States

Salina Regional Health Center

🇺🇸

Salina, Kansas, United States

University of Kansas Health System Saint Francis Campus

🇺🇸

Topeka, Kansas, United States

Cancer Center of Kansas - Wichita

🇺🇸

Wichita, Kansas, United States

Oncology Hematology Care Inc-Crestview

🇺🇸

Crestview Hills, Kentucky, United States

Baptist Health Hardin

🇺🇸

Elizabethtown, Kentucky, United States

Baptist Health Lexington

🇺🇸

Lexington, Kentucky, United States

Ochsner Health Center-Summa

🇺🇸

Baton Rouge, Louisiana, United States

Ochsner Medical Center Jefferson

🇺🇸

New Orleans, Louisiana, United States

Bixby Medical Center

🇺🇸

Adrian, Michigan, United States

Hickman Cancer Center

🇺🇸

Adrian, Michigan, United States

Michigan Cancer Research Consortium NCORP

🇺🇸

Ann Arbor, Michigan, United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

🇺🇸

Ann Arbor, Michigan, United States

Bronson Battle Creek

🇺🇸

Battle Creek, Michigan, United States

Corewell Health Dearborn Hospital

🇺🇸

Dearborn, Michigan, United States

Henry Ford Health Saint John Hospital

🇺🇸

Detroit, Michigan, United States

OSF Saint Francis Hospital and Medical Group

🇺🇸

Escanaba, Michigan, United States

Genesys Hurley Cancer Institute

🇺🇸

Flint, Michigan, United States

Hurley Medical Center

🇺🇸

Flint, Michigan, United States

Cancer Research Consortium of West Michigan NCORP

🇺🇸

Grand Rapids, Michigan, United States

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

🇺🇸

Grand Rapids, Michigan, United States

Trinity Health Grand Rapids Hospital

🇺🇸

Grand Rapids, Michigan, United States

Allegiance Health

🇺🇸

Jackson, Michigan, United States

University of Michigan Health - Sparrow Lansing

🇺🇸

Lansing, Michigan, United States

Trinity Health Saint Mary Mercy Livonia Hospital

🇺🇸

Livonia, Michigan, United States

Mercy Memorial Hospital

🇺🇸

Monroe, Michigan, United States

Toledo Clinic Cancer Centers-Monroe

🇺🇸

Monroe, Michigan, United States

Trinity Health Muskegon Hospital

🇺🇸

Muskegon, Michigan, United States

Corewell Health Lakeland Hospitals - Niles Hospital

🇺🇸

Niles, Michigan, United States

Trinity Health Saint Joseph Mercy Oakland Hospital

🇺🇸

Pontiac, Michigan, United States

Lake Huron Medical Center

🇺🇸

Port Huron, Michigan, United States

Corewell Health Reed City Hospital

🇺🇸

Reed City, Michigan, United States

MyMichigan Medical Center Saginaw

🇺🇸

Saginaw, Michigan, United States

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

🇺🇸

Saint Joseph, Michigan, United States

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

🇺🇸

Saint Joseph, Michigan, United States

Munson Medical Center

🇺🇸

Traverse City, Michigan, United States

Henry Ford Health Warren Hospital

🇺🇸

Warren, Michigan, United States

Fairview Ridges Hospital

🇺🇸

Burnsville, Minnesota, United States

Essentia Health Cancer Center

🇺🇸

Duluth, Minnesota, United States

Essentia Health Saint Mary's Medical Center

🇺🇸

Duluth, Minnesota, United States

Miller-Dwan Hospital

🇺🇸

Duluth, Minnesota, United States

Fairview Southdale Hospital

🇺🇸

Edina, Minnesota, United States

Unity Hospital

🇺🇸

Fridley, Minnesota, United States

Hutchinson Area Health Care

🇺🇸

Hutchinson, Minnesota, United States

Minnesota Oncology Hematology PA-Maplewood

🇺🇸

Maplewood, Minnesota, United States

Saint John's Hospital - Healtheast

🇺🇸

Maplewood, Minnesota, United States

Abbott-Northwestern Hospital

🇺🇸

Minneapolis, Minnesota, United States

Hennepin County Medical Center

🇺🇸

Minneapolis, Minnesota, United States

Health Partners Inc

🇺🇸

Minneapolis, Minnesota, United States

New Ulm Medical Center

🇺🇸

New Ulm, Minnesota, United States

North Memorial Medical Health Center

🇺🇸

Robbinsdale, Minnesota, United States

Mayo Clinic in Rochester

🇺🇸

Rochester, Minnesota, United States

Metro Minnesota Community Oncology Research Consortium

🇺🇸

Saint Louis Park, Minnesota, United States

Park Nicollet Clinic - Saint Louis Park

🇺🇸

Saint Louis Park, Minnesota, United States

Regions Hospital

🇺🇸

Saint Paul, Minnesota, United States

United Hospital

🇺🇸

Saint Paul, Minnesota, United States

Saint Francis Regional Medical Center

🇺🇸

Shakopee, Minnesota, United States

Lakeview Hospital

🇺🇸

Stillwater, Minnesota, United States

Ridgeview Medical Center

🇺🇸

Waconia, Minnesota, United States

Rice Memorial Hospital

🇺🇸

Willmar, Minnesota, United States

Minnesota Oncology Hematology PA-Woodbury

🇺🇸

Woodbury, Minnesota, United States

Cox Cancer Center Branson

🇺🇸

Branson, Missouri, United States

Mercy Cancer Center - Cape Girardeau

🇺🇸

Cape Girardeau, Missouri, United States

MU Health - University Hospital/Ellis Fischel Cancer Center

🇺🇸

Columbia, Missouri, United States

Centerpoint Medical Center LLC

🇺🇸

Independence, Missouri, United States

MU Health Care Goldschmidt Cancer Center

🇺🇸

Jefferson City, Missouri, United States

Mercy Hospital Joplin

🇺🇸

Joplin, Missouri, United States

University Health Truman Medical Center

🇺🇸

Kansas City, Missouri, United States

Saint Luke's Hospital of Kansas City

🇺🇸

Kansas City, Missouri, United States

Heartland Hematology and Oncology Associates Incorporated

🇺🇸

Kansas City, Missouri, United States

The University of Kansas Cancer Center-South

🇺🇸

Kansas City, Missouri, United States

Research Medical Center

🇺🇸

Kansas City, Missouri, United States

University of Kansas Cancer Center - North

🇺🇸

Kansas City, Missouri, United States

University of Kansas Cancer Center - Lee's Summit

🇺🇸

Lee's Summit, Missouri, United States

Saint Luke's East - Lee's Summit

🇺🇸

Lee's Summit, Missouri, United States

Liberty Radiation Oncology Center

🇺🇸

Liberty, Missouri, United States

Mercy Clinic-Rolla-Cancer and Hematology

🇺🇸

Rolla, Missouri, United States

Phelps Health Delbert Day Cancer Institute

🇺🇸

Rolla, Missouri, United States

Heartland Regional Medical Center

🇺🇸

Saint Joseph, Missouri, United States

Saint Louis Cancer and Breast Institute-South City

🇺🇸

Saint Louis, Missouri, United States

Washington University School of Medicine

🇺🇸

Saint Louis, Missouri, United States

Missouri Baptist Medical Center

🇺🇸

Saint Louis, Missouri, United States

Mercy Hospital Saint Louis

🇺🇸

Saint Louis, Missouri, United States

Cancer Research for the Ozarks NCORP

🇺🇸

Springfield, Missouri, United States

Mercy Hospital Springfield

🇺🇸

Springfield, Missouri, United States

CoxHealth South Hospital

🇺🇸

Springfield, Missouri, United States

Billings Clinic Cancer Center

🇺🇸

Billings, Montana, United States

Saint Vincent Healthcare

🇺🇸

Billings, Montana, United States

Montana Cancer Consortium NCORP

🇺🇸

Billings, Montana, United States

Bozeman Health Deaconess Hospital

🇺🇸

Bozeman, Montana, United States

Saint James Community Hospital and Cancer Treatment Center

🇺🇸

Butte, Montana, United States

Benefis Sletten Cancer Institute

🇺🇸

Great Falls, Montana, United States

Saint Peter's Community Hospital

🇺🇸

Helena, Montana, United States

Logan Health Medical Center

🇺🇸

Kalispell, Montana, United States

Saint Patrick Hospital - Community Hospital

🇺🇸

Missoula, Montana, United States

Nebraska Cancer Research Center

🇺🇸

Lincoln, Nebraska, United States

Missouri Valley Cancer Consortium

🇺🇸

Omaha, Nebraska, United States

Nebraska Methodist Hospital

🇺🇸

Omaha, Nebraska, United States

Alegent Health Immanuel Medical Center

🇺🇸

Omaha, Nebraska, United States

Alegent Health Bergan Mercy Medical Center

🇺🇸

Omaha, Nebraska, United States

Alegent Health Lakeside Hospital

🇺🇸

Omaha, Nebraska, United States

Creighton University Medical Center

🇺🇸

Omaha, Nebraska, United States

Cancer and Blood Specialists-Henderson

🇺🇸

Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada - Henderson

🇺🇸

Henderson, Nevada, United States

Las Vegas Cancer Center-Henderson

🇺🇸

Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada-Southeast Henderson

🇺🇸

Henderson, Nevada, United States

GenesisCare USA - Henderson

🇺🇸

Henderson, Nevada, United States

University Medical Center of Southern Nevada

🇺🇸

Las Vegas, Nevada, United States

Cancer and Blood Specialists-Shadow

🇺🇸

Las Vegas, Nevada, United States

Radiation Oncology Centers of Nevada Central

🇺🇸

Las Vegas, Nevada, United States

GenesisCare USA - Las Vegas

🇺🇸

Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

🇺🇸

Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-San Martin

🇺🇸

Las Vegas, Nevada, United States

Radiation Oncology Centers of Nevada Southeast

🇺🇸

Las Vegas, Nevada, United States

Cancer Therapy and Integrative Medicine

🇺🇸

Las Vegas, Nevada, United States

Cancer and Blood Specialists-Tenaya

🇺🇸

Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Northwest

🇺🇸

Las Vegas, Nevada, United States

GenesisCare USA - Vegas Tenaya

🇺🇸

Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

🇺🇸

Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada-Summerlin

🇺🇸

Las Vegas, Nevada, United States

Las Vegas Cancer Center-Medical Center

🇺🇸

Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada

🇺🇸

Las Vegas, Nevada, United States

GenesisCare USA - Fort Apache

🇺🇸

Las Vegas, Nevada, United States

OptumCare Cancer Care at Fort Apache

🇺🇸

Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

🇺🇸

Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Central Valley

🇺🇸

Las Vegas, Nevada, United States

Nevada Cancer Research Foundation NCORP

🇺🇸

Las Vegas, Nevada, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

🇺🇸

Lebanon, New Hampshire, United States

Cooper Hospital University Medical Center

🇺🇸

Camden, New Jersey, United States

Rutgers Cancer Institute of New Jersey

🇺🇸

New Brunswick, New Jersey, United States

University of New Mexico Cancer Center

🇺🇸

Albuquerque, New Mexico, United States

Memorial Medical Center-Las Cruces

🇺🇸

Las Cruces, New Mexico, United States

Montefiore Medical Center-Einstein Campus

🇺🇸

Bronx, New York, United States

Montefiore Medical Center - Moses Campus

🇺🇸

Bronx, New York, United States

Glens Falls Hospital

🇺🇸

Glens Falls, New York, United States

University of Rochester

🇺🇸

Rochester, New York, United States

Syracuse Veterans Administration Medical Center

🇺🇸

Syracuse, New York, United States

UNC Lineberger Comprehensive Cancer Center

🇺🇸

Chapel Hill, North Carolina, United States

Wayne Memorial Hospital

🇺🇸

Goldsboro, North Carolina, United States

Margaret R Pardee Memorial Hospital

🇺🇸

Hendersonville, North Carolina, United States

ECU Health Oncology Kinston

🇺🇸

Kinston, North Carolina, United States

Iredell Memorial Hospital

🇺🇸

Statesville, North Carolina, United States

Essentia Health Cancer Center-South University Clinic

🇺🇸

Fargo, North Dakota, United States

Strecker Cancer Center-Belpre

🇺🇸

Belpre, Ohio, United States

Toledo Clinic Cancer Centers-Bowling Green

🇺🇸

Bowling Green, Ohio, United States

Adena Regional Medical Center

🇺🇸

Chillicothe, Ohio, United States

Oncology Hematology Care Inc-Eden Park

🇺🇸

Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Mercy West

🇺🇸

Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Anderson

🇺🇸

Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Kenwood

🇺🇸

Cincinnati, Ohio, United States

Oncology Hematology Care Inc-Blue Ash

🇺🇸

Cincinnati, Ohio, United States

Case Western Reserve University

🇺🇸

Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center

🇺🇸

Columbus, Ohio, United States

Columbus Oncology and Hematology Associates Inc

🇺🇸

Columbus, Ohio, United States

Riverside Methodist Hospital

🇺🇸

Columbus, Ohio, United States

Columbus NCI Community Oncology Research Program

🇺🇸

Columbus, Ohio, United States

Grant Medical Center

🇺🇸

Columbus, Ohio, United States

The Mark H Zangmeister Center

🇺🇸

Columbus, Ohio, United States

Mount Carmel Health Center West

🇺🇸

Columbus, Ohio, United States

Doctors Hospital

🇺🇸

Columbus, Ohio, United States

Good Samaritan Hospital - Dayton

🇺🇸

Dayton, Ohio, United States

Miami Valley Hospital

🇺🇸

Dayton, Ohio, United States

Miami Valley Hospital North

🇺🇸

Dayton, Ohio, United States

Dayton NCI Community Oncology Research Program

🇺🇸

Dayton, Ohio, United States

Delaware Health Center-Grady Cancer Center

🇺🇸

Delaware, Ohio, United States

Delaware Radiation Oncology

🇺🇸

Delaware, Ohio, United States

Grady Memorial Hospital

🇺🇸

Delaware, Ohio, United States

Oncology Hematology Care Inc-Healthplex

🇺🇸

Fairfield, Ohio, United States

Blanchard Valley Hospital

🇺🇸

Findlay, Ohio, United States

Atrium Medical Center-Middletown Regional Hospital

🇺🇸

Franklin, Ohio, United States

Wayne Hospital

🇺🇸

Greenville, Ohio, United States

Kettering Medical Center

🇺🇸

Kettering, Ohio, United States

Fairfield Medical Center

🇺🇸

Lancaster, Ohio, United States

Lancaster Radiation Oncology

🇺🇸

Lancaster, Ohio, United States

Lima Memorial Hospital

🇺🇸

Lima, Ohio, United States

Marietta Memorial Hospital

🇺🇸

Marietta, Ohio, United States

Toledo Clinic Cancer Centers-Maumee

🇺🇸

Maumee, Ohio, United States

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center

🇺🇸

Maumee, Ohio, United States

Knox Community Hospital

🇺🇸

Mount Vernon, Ohio, United States

Licking Memorial Hospital

🇺🇸

Newark, Ohio, United States

Newark Radiation Oncology

🇺🇸

Newark, Ohio, United States

Saint Charles Hospital

🇺🇸

Oregon, Ohio, United States

Toledo Clinic Cancer Centers-Oregon

🇺🇸

Oregon, Ohio, United States

Southern Ohio Medical Center

🇺🇸

Portsmouth, Ohio, United States

Springfield Regional Medical Center

🇺🇸

Springfield, Ohio, United States

ProMedica Flower Hospital

🇺🇸

Sylvania, Ohio, United States

Mercy Hospital of Tiffin

🇺🇸

Tiffin, Ohio, United States

Mercy Health - Saint Vincent Hospital

🇺🇸

Toledo, Ohio, United States

University of Toledo

🇺🇸

Toledo, Ohio, United States

Toledo Community Hospital Oncology Program CCOP

🇺🇸

Toledo, Ohio, United States

Mercy Health - Saint Anne Hospital

🇺🇸

Toledo, Ohio, United States

Toledo Clinic Cancer Centers-Toledo

🇺🇸

Toledo, Ohio, United States

Upper Valley Medical Center

🇺🇸

Troy, Ohio, United States

Fulton County Health Center

🇺🇸

Wauseon, Ohio, United States

Saint Ann's Hospital

🇺🇸

Westerville, Ohio, United States

Genesis Healthcare System Cancer Care Center

🇺🇸

Zanesville, Ohio, United States

Cancer Centers of Southwest Oklahoma Research

🇺🇸

Lawton, Oklahoma, United States

University of Oklahoma Health Sciences Center

🇺🇸

Oklahoma City, Oklahoma, United States

Oklahoma Cancer Specialists and Research Institute-Tulsa

🇺🇸

Tulsa, Oklahoma, United States

Clackamas Radiation Oncology Center

🇺🇸

Clackamas, Oregon, United States

Providence Milwaukie Hospital

🇺🇸

Milwaukie, Oregon, United States

Providence Newberg Medical Center

🇺🇸

Newberg, Oregon, United States

Providence Willamette Falls Medical Center

🇺🇸

Oregon City, Oregon, United States

Providence Portland Medical Center

🇺🇸

Portland, Oregon, United States

Providence Saint Vincent Medical Center

🇺🇸

Portland, Oregon, United States

Saint Luke's University Hospital-Bethlehem Campus

🇺🇸

Bethlehem, Pennsylvania, United States

Geisinger Medical Center

🇺🇸

Danville, Pennsylvania, United States

Geisinger Medical Center-Cancer Center Hazleton

🇺🇸

Hazleton, Pennsylvania, United States

Guthrie Medical Group PC-Robert Packer Hospital

🇺🇸

Sayre, Pennsylvania, United States

Geisinger Medical Group

🇺🇸

State College, Pennsylvania, United States

Geisinger Wyoming Valley/Henry Cancer Center

🇺🇸

Wilkes-Barre, Pennsylvania, United States

UPMC Susquehanna

🇺🇸

Williamsport, Pennsylvania, United States

Prisma Health Cancer Institute - Spartanburg

🇺🇸

Boiling Springs, South Carolina, United States

McLeod Regional Medical Center

🇺🇸

Florence, South Carolina, United States

Prisma Health Cancer Institute - Butternut

🇺🇸

Greenville, South Carolina, United States

Prisma Health Cancer Institute - Faris

🇺🇸

Greenville, South Carolina, United States

Prisma Health Greenville Memorial Hospital

🇺🇸

Greenville, South Carolina, United States

Prisma Health Cancer Institute - Eastside

🇺🇸

Greenville, South Carolina, United States

Prisma Health Cancer Institute - Greer

🇺🇸

Greer, South Carolina, United States

Prisma Health Cancer Institute - Seneca

🇺🇸

Seneca, South Carolina, United States

Rapid City Regional Hospital

🇺🇸

Rapid City, South Dakota, United States

Baylor University Medical Center

🇺🇸

Dallas, Texas, United States

Houston Methodist Hospital

🇺🇸

Houston, Texas, United States

University of Texas Health Science Center at San Antonio

🇺🇸

San Antonio, Texas, United States

American Fork Hospital / Huntsman Intermountain Cancer Center

🇺🇸

American Fork, Utah, United States

Sandra L Maxwell Cancer Center

🇺🇸

Cedar City, Utah, United States

Logan Regional Hospital

🇺🇸

Logan, Utah, United States

Intermountain Medical Center

🇺🇸

Murray, Utah, United States

McKay-Dee Hospital Center

🇺🇸

Ogden, Utah, United States

Utah Valley Regional Medical Center

🇺🇸

Provo, Utah, United States

Saint George Regional Medical Center

🇺🇸

Saint George, Utah, United States

Utah Cancer Specialists-Salt Lake City

🇺🇸

Salt Lake City, Utah, United States

LDS Hospital

🇺🇸

Salt Lake City, Utah, United States

Southwestern Vermont Medical Center

🇺🇸

Bennington, Vermont, United States

Fredericksburg Oncology Inc

🇺🇸

Fredericksburg, Virginia, United States

PeaceHealth Southwest Medical Center

🇺🇸

Vancouver, Washington, United States

Compass Oncology Vancouver

🇺🇸

Vancouver, Washington, United States

Edwards Comprehensive Cancer Center

🇺🇸

Huntington, West Virginia, United States

Marshfield Clinic-Chippewa Center

🇺🇸

Chippewa Falls, Wisconsin, United States

HSHS Sacred Heart Hospital

🇺🇸

Eau Claire, Wisconsin, United States

Marshfield Clinic Cancer Center at Sacred Heart

🇺🇸

Eau Claire, Wisconsin, United States

Green Bay Oncology at Saint Vincent Hospital

🇺🇸

Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center Green Bay

🇺🇸

Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Saint Mary's

🇺🇸

Green Bay, Wisconsin, United States

University of Wisconsin Carbone Cancer Center - University Hospital

🇺🇸

Madison, Wisconsin, United States

Holy Family Memorial Hospital

🇺🇸

Manitowoc, Wisconsin, United States

Marshfield Medical Center-Marshfield

🇺🇸

Marshfield, Wisconsin, United States

Marshfield Medical Center

🇺🇸

Marshfield, Wisconsin, United States

Medical College of Wisconsin

🇺🇸

Milwaukee, Wisconsin, United States

Marshfield Medical Center - Minocqua

🇺🇸

Minocqua, Wisconsin, United States

Cancer Center of Western Wisconsin

🇺🇸

New Richmond, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Oconto Falls

🇺🇸

Oconto Falls, Wisconsin, United States

Aspirus Cancer Care - James Beck Cancer Center

🇺🇸

Rhinelander, Wisconsin, United States

Saint Mary's Hospital

🇺🇸

Rhinelander, Wisconsin, United States

Marshfield Medical Center-Rice Lake

🇺🇸

Rice Lake, Wisconsin, United States

HSHS Saint Nicholas Hospital

🇺🇸

Sheboygan, Wisconsin, United States

Aspirus Cancer Care - Stevens Point

🇺🇸

Stevens Point, Wisconsin, United States

Marshfield Clinic-Wausau Center

🇺🇸

Wausau, Wisconsin, United States

Ascension Saint Clare's Hospital

🇺🇸

Weston, Wisconsin, United States

Marshfield Medical Center - Weston

🇺🇸

Weston, Wisconsin, United States

Marshfield Clinic - Wisconsin Rapids Center

🇺🇸

Wisconsin Rapids, Wisconsin, United States

Rocky Mountain Oncology

🇺🇸

Casper, Wyoming, United States

Welch Cancer Center

🇺🇸

Sheridan, Wyoming, United States

Arthur J E Child Comprehensive Cancer Centre

🇨🇦

Calgary, Alberta, Canada

BCCA-Vancouver Cancer Centre

🇨🇦

Vancouver, British Columbia, Canada

The Vitalite Health Network - Dr Leon Richard Oncology Centre

🇨🇦

Moncton, New Brunswick, Canada

QEII Health Sciences Centre/Nova Scotia Health Authority

🇨🇦

Halifax, Nova Scotia, Canada

Juravinski Cancer Centre at Hamilton Health Sciences

🇨🇦

Hamilton, Ontario, Canada

Grand River Regional Cancer Centre at Grand River Hospital

🇨🇦

Kitchener, Ontario, Canada

Ottawa Hospital and Cancer Center-General Campus

🇨🇦

Ottawa, Ontario, Canada

University Health Network-Princess Margaret Hospital

🇨🇦

Toronto, Ontario, Canada

CHUM - Hopital Notre-Dame

🇨🇦

Montreal, Quebec, Canada

CHUM - Centre Hospitalier de l'Universite de Montreal

🇨🇦

Montreal, Quebec, Canada

Allan Blair Cancer Centre

🇨🇦

Regina, Saskatchewan, Canada

Saskatoon Cancer Centre

🇨🇦

Saskatoon, Saskatchewan, Canada

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