NL-OMON48648已完成3 期
Vitamin D3: Identification of central nervous system targets using high-technology functional MRI (D-LIGHTFUL) - D-LIGHTF
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Age between 18 - 35 years
- •- Ability to provide informed consent
- •- Right-handedness
- •- Stable weight (<5% change) for 3 months prior to study assessment,
- •Additionally, for the obese subset:
- •- BMI between 30 - 40 kg/m2
- •- Metabolically unhealthy, defined as fasting plasma insulin levels >74 pmol/l
- •at screening
排除标准
- •- Any medical or psychiatrical disorder (except stable obesity-related glucose
- •intolerance, hypertension, dyslipidemia and/or controlled hypothyroidism)
- •- Subjects taking any of the following medications: anticonvulsants,
- •corticosteroids, digitalis, magnesium-containing preparations (e.g. antacids),
- •thiazide-diuretics, phosphodiesterase inhibitors, serotonergic medications
- •(e.g. SSRI, SNRI, MAO inhibitors, buproprion, tricyclic antidepressants, St.
- •John*s Wort), codeine (CYP2D6 inhibition), tamoxifen, timolol, warfarin,
- •exogenous insulin, GLP-1 agonists, DPP4 inhibitors, SGLT2 inhibitors,
- •beta-blockers, homeopathic supplements
- •- The use of weight loss agents (e.g. orlistat, phentermine, topiramate,
- •fenfluramin, dexfenfluramine, amphetamines, GLP-1 agonists) or use within 3
- •months prior to study
- •- Weight loss surgery or gastrectomy
- •- Childhood-onset obesity
- •- Breakfast skippers
- •- Shift workers
- •- Contraindication to MRI scanning (e.g. claustrophobia, pacemaker, metal IUD)
- •- Significant sensory or motor impairment
- •- Subjects who cannot adhere to the experimental protocol for any reason
研究者
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