A two-arm pragmatic randomised control trial comparing the clinical and cost-effectiveness of serratus anterior plane block (SAP) in reducing the rate of respiratory infections 5 days post randomisation in patients with multiple rib fractures (MRF) when compared with the usual care in the NHS trauma setting

Not Applicable

• Conditions: Multiple rib fractures; Surgery

• Registration Number: ISRCTN16156075
• Lead Sponsor: niversity of Birmingham

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-10-24
• Last Update Posted: 27 March 2023
• Study Completion: 2026-07-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 824

Inclusion Criteria

1. Patients >=16 years with unilateral or bilateral >=3 rib fractures following blunt chest trauma
2. Injury occurred <=72 hours of hospital admission

Exclusion Criteria

1. Severe traumatic brain injury with a predicted ventilatory requirement >7 days
2. Acute quadriparesis
3. Spinal fracture precluding mobilisation
4. Penetrating trauma or open rib fractures
5. Upper airway injury requiring intubation and mechanical ventilation with an expected dependency of more than 5 days (e.g. tracheal disruption)
6. Any chest wall injuries that preclude a catheter insertion
7. Not anticipated to survive >= 48 hours
8. Contamination or infection at site of potential SAP insertion
9. Any contraindication for the treating clinician for SAP block catheter insertion
10. Patients of childbearing age who have tested positive for pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified