Search for Predictors of Therapeutic Response in Patients With Carcinoma of the Ovary, the Fallopian Tube or Peritoneal Serous-type Advanced
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 107
- 试验地点
- 14
- 主要终点
- search for predictors of response to chemotherapy
研究概览
简要总结
In order to search for predictors of response to chemotherapy in patients with ovarian carcinoma of the ovary, the fallopian tube or peritoneal serous-type advanced stage, we will define the comparative profiles of miRNA expression of serum polymorphisms and determine differential in 2 patient populations (with or without recurrence 6 months after completion of chemotherapy) with (i) the miRNA profile of serum before treatment and (ii) identification of polymorphisms or SNP (Single Nucleotide Polymorphism) in particular genes involved in the metabolism of chemotherapy agents In the case of miRNA, expression profiles will also be studied during the first course in response to chemotherapy. Indeed, the miRNA profile of serum may be different at baseline among the 2 types of populations (or non-recurrence at 6 months).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients with cancer of the ovary, peritoneum or of the fallopian tube
- •Stage III or IV
- •Cancer of serous histology
- •Patients of any chemotherapy naive
- •Patients should receive treatment with chemotherapy for first line by Taxol- Carboplatin. Avastin is authorized in concomitant.
- •An initial surgery or through authorized
- •Patients who signed informed consent
- •Patients over the age of 18 years
排除标准
- •Patients being treated for another cancer chemotherapy and / or hormone therapy
- •Patients receiving other chemotherapy Taxol-carboplatin associated or not to avastin
- •Patients under guardianship
- •Previous history of pelvic radiotherapy
- •History of malignancy blood
结局指标
主要结局
search for predictors of response to chemotherapy
时间窗: 12 months after beginning treatment
the search for predictors of response to chemotherapy in patients with carcinoma of the ovary, the fallopian tube or peritoneal serous-type advanced by using (i) the miRNA profile of serum before treatment with chemotherapy and (ii) the identification of polymorphisms or SNPs (Single Nucleotide polymorphism) in particular genes involved in the metabolism of chemotherapy agents
次要结局
- profiling miRNA expression(1 month)
- study of changes in serum miRNA expression(6 months)