Exercise and Parkinson's Disease: The Basis for Motor and Cognitive Benefits
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- Pacific Parkinson's Research Centre
- Enrollment
- 26
- Locations
- 1
- Primary Endpoint
- Change in Dopamine release measured by RAC PET
- Status
- Terminated
- Last Updated
- 5 years ago
Overview
Brief Summary
The therapeutic effects of exercise in Parkinson's disease (PD) are commonly reported, however the mechanisms are unknown. The purpose of this study is to investigate the potential mechanisms of exercise in the brain for the treatment of PD.
Detailed Description
Positron Emission Tomography will be used to measure dopamine neuron density, endogenous dopamine release and neuroimflammation. We will also use functional magnetic resonance imaging (fMRI) to measure brain activity. Assessments will be conducted before and after a 12-week exercise intervention and 3-year follow-up. Participants will be randomly allocated into either an aerobic or a stretching intervention. Clinical measures of motor function, cognition and mood will also be assessed.
Investigators
A. Jon Stoessl
Director of Clinical PET
Pacific Parkinson's Research Centre
Eligibility Criteria
Inclusion Criteria
- •Diagnosed with Parkinson's Disease, Exercise less than 3x per week.
- •Exclusion Criteria. Describe which potential participants will be excluded from participation, and list the criteria for their exclusion.
- •atypical Parkinson syndrome (progressive supranuclear palsy, multiple system atrophy, drug-induced etc.);
- •significant osteoporosis or arthritis;
- •other neurological disease/complications (e.g. myopathy, stroke, brain lesion, MS);
- •self-reports claustrophobia;
- •history of cancer within 5 years of study participation;
- •high dose of radiation from other procedures within the year;
- •not able to tolerate being off PD medication for up to 24 hours;
- •a female subject who is breast-feeding or pregnant.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change in Dopamine release measured by RAC PET
Time Frame: 4 months