Pathology-guided treatment of rectal cancer

Not Applicable

Completed

• Conditions: Rectal cancer; Cancer

• Registration Number: ISRCTN28785842
• Lead Sponsor: Medical Research Council (MRC) (UK)

Brief Summary

2009 results in: 1. Initial results: http://www.ncbi.nlm.nih.gov/pubmed/19269519 2. Prospective study results: http://www.ncbi.nlm.nih.gov/pubmed/19269520

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2000-04-06
• Study Completion: 2005-08-05
• Last Update Posted: 12 November 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1350

Inclusion Criteria

1. Histologically confirmed adenocarcinoma of the rectum
2. Considered potentially operable
3. No evidence of metastases
4. Patient considered fit to receive either arm of the trial
5. No concurrent uncontrolled medical illness
6. No previous or current malignant disease likely to interfere with treatment or comparisons
7. Informed consent obtained

Exclusion Criteria

Not provided at time of registration

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ocal recurrence (as defined using an algorithm designed for the trial).

Secondary Outcome Measures

Name	Time	Method
1. Local recurrence-free survival<br>2. Overall survival<br>3. Time to appearance of distant metastases<br>4. Disease-free survival<br>5. Morbidity<br>6. Quality of life <br>7. Economic implications