Comparing the efficacy of azathioprine and mycophenolate mofetil in patients with sunlight induced dermatitis
Not Applicable
Completed
- Conditions
- Health Condition 1: L308- Other specified dermatitis
- Registration Number
- CTRI/2021/12/038801
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients diagnosed as chronic actinic dermatitis.
2.Age >18 years.
Exclusion Criteria
1.Patients with hepatic/ renal disease/peptic ulcer disease.
2.Severe anaemia ( <10 gm/dl), leucopenia ( <3500-4000/mm3 ) or thrombocytopenia ( <100,000/mm3.)
3.Active infectious disease or immune system deficiency including AIDS.
4.Pregnant or lactating women.
5.Significant abnormalities in liver function (serum bilirubin, AST, ALT, and ALP > 1.5 times the upper limit of normal), viral hepatitis or cirrhosis.
6.H/o intolerance/hypersensitivity to azathioprine and/or mycophenolate mofetil.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ·To compare the clinical and functional outcome after 3 months in each group, as assessed by EASI and DLQI. <br/ ><br>·To compare the safety and tolerability of each drug by regular evaluation of clinical and biochemical parameters. <br/ ><br>Timepoint: Week 2, week 4, week 8, week 12 <br/ ><br>
- Secondary Outcome Measures
Name Time Method ·Identification of the clinicodemographic factors predicting clinical outcome in each group.Timepoint: Baseline and week 12