IRCT20210423051054N1
Not yet recruiting
Phase 3
Evaluation of therapeutic effect of placental mesenchymal stem cell exosome injection in improving clinical symptoms and MRI changes in patients with knee osteoarthritis
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Knee osteoarthritis.
- Sponsor
- Shahid Beheshti University of Medical Sciences
- Enrollment
- 30
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Pain in both knees over the past 6 months, which is related to the degenerative process of the knee, requires pain medication and has lasted for more than a month.
- •Graphical confirmation of bilateral knee osteoarthritis with grade 2 or 3 based on the Kellgren\-Lawrence classification.
- •The knee pain intensity should be greater than or equal to 4 according to the VAS.
Exclusion Criteria
- •Younger than 45 years or older than 65 years
- •Rheumatic or collagen vascular disease
- •History of malignancy
- •Coagulopathy or taking anticoagulant drug
- •Any injection into the knee joint during the last 3 months
- •A history of recent severe knee trauma in the past 1 month
- •Septic arthritis of the knee or active wound of the knee joint
- •Genovarum or genovalgum greater than 20 degrees
- •Total knee replacement
- •Cardiac pacemaker
Outcomes
Primary Outcomes
Not specified
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