COVID-19 Stroke Apical Lung Examination Study - A Multi-centre Prospective Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 2,000
- 试验地点
- 12
- 主要终点
- Accuracy of the computed tomography angiography biomarker relative to the COVID-19 RT-PCR test
研究概览
简要总结
Multi-centre prospective study evaluating computed tomography angiography studies performed for stroke patients as a diagnostic and prognostic imaging biomarker.
详细描述
Diagnosis of coronavirus disease 2019 (COVID-19) relies on clinical features and reverse-transcriptase polymerase chain reaction (RT-PCR) testing. The latter is constrained by limited sensitivity and a timescale of hours to yield results, with no point-of-care test widely available. A dedicated computed tomography study of the chest is likely to be more sensitive than RT-PCR for COVID-19. Carotid computed tomography angiography (CTA) is a routine acute stroke investigation and includes the lung apices. We aim to assess the lung apices on CTA for ground glass opacification and compare this with COVID-19 RT-PCR test results and clinical outcome measures.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All adult patients presenting with clinical features of acute ischaemic stroke undergoing investigation with computed tomography angiography at presentation.
排除标准
- •Poor image quality. No radiologist report available. Computed tomography angiography performed in a non-acute setting.
结局指标
主要结局
Accuracy of the computed tomography angiography biomarker relative to the COVID-19 RT-PCR test
时间窗: 1 month
Defined by sensitivity, specificity, positive and negative predictive values
次要结局
- Prognostic value of the computed tomography biomarker(1 month)