Comparing efficacy of different topical antibiotics benzoyl peroxide vs clindamycin vs minocycline) in management of grade 2 acne
Phase 3
- Conditions
- Health Condition 1: L700- Acne vulgaris
- Registration Number
- CTRI/2024/07/071616
- Lead Sponsor
- Jyotsana Naikwadi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All adult patients diagnosed with acne vulgaris grade II & III
Exclusion Criteria
Patient unwilling to give consent to be part of trial.
Pregnant, lactating female and patients planning pregnancy during trial period.
Patient with nodulocystic lesion, acne conglobata, acne fulminans, secondary acne, acne excoriata (e.g. chloracne, drug induced acne) or any other acne requiring systemic treatment.
People suffering from photosensitivity disorders.
Patient who has abnormal baseline investigations. Clinically significant hepatic impairement.
History of DRESS syndrome, serum sickness, vasculitis.
History of hypersensitivity to benzoyl peroxide, clindamycin, minocycline.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Compar efficacy of therapy with respect to decrease in number of lesionsTimepoint: Calculation of Global Acne Grading score. <br/ ><br>Assessment of clinical photographs by blinded physician by percentage response scale. <br/ ><br>Patient satisfaction measured according to 5 point liker scale. <br/ ><br>Measured at baseline, 4 week, 8 weeks, 12 weeks and 3 months post treatment.
- Secondary Outcome Measures
Name Time Method Analyse the safety & tolerability of different antibiotics benzoyl peroxide vs clindamycin vs minocycline with respect to adverse effect related to therapyTimepoint: Compared at baseline,during course of therapy at 4 week, 8week, 12week & end of post treatment follow up period I.e.after 3 month.