Efficacy of Buprenorphine and Fentanyl transdermal patches in managing postoperative pain following lower limb orthopaedic surgeries - A double blinded randomised controlled trial

This study is a comparative evaluation of buprenorphine (10 µg/h) and fentanyl (25 µg/h) transdermal patches in the context of lower limb orthopedic surgeries in patients with BMI of more than 25. This study aims to assess the analgesic efficacy of these patches, alongside noting hemodynamic variability and potential adverse effects, to establish optimized pain management strategies for patients undergoing lower limb orthopaedic procedures.Preoperative phase

1. Patient screening :

Eligible patients will be identified based on the inclusion and exclusion criteria

Written informed consent will be obtained from all participants

2. Baseline data collection :

Demographic details ( Age, gender, weight, BMI)

Preop pain assessment and medical history

Details of the planned surgical procedure

Intraoperative phase

1. Standardized anaesthetic protocol :

All patients will receive the same anaesthesia regimen to minimise variability in postoperative pain outcomes.

Duration and type of surgery will be recorded.

2. Application of Transdermal patches will be applied within 2 hours post surgery

Postoperative phase

1. Pain assessment

Pain scores will be recorded using the VAS score at fixed time intervals :

6,12,24,48, and 72 hours postoperatively

2. Adverse effects monitoring

Patient will be monitored  for opioid – related side effects (nausea,vomiting,dizziness, respiratory depression)

3. Patient satisfaction