NCT04335383招募中不适用
Isolation of Human Recombinant Therapeutic Monoclonal Anti-Pseudomonas Antibodies From B Lymphocytes of Patients Who Have Been Followed for Infection or Colonization With Pseudomonas Aeruginosa: a Prospective Monocentric Trial
University Hospital, Grenoble1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2020年10月5日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Isolation of recombinant human monoclonal antibodies against Pseudomonas aeruginosa
研究概览
简要总结
Pseudomonas aeruginosa is a pathogenic bacteria for human, especially in hospital settings. It can sometimes be multi-resistant to many or even to all antibiotics usually used for its treatment.
The aim of the study is to isolate and produce therapeutic antibodies against the bacteria Pseudomonas aeruginosa in order to provide an alternative treatment to antibiotics in case of infection with an antibiotic-resistant strain of Pseudomonas aeruginosa.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient selected in the retrospective part of the study (patient with serum containing functional anti-Pseudomonas aeruginosa antibodies)
- •Patient with weight ≥ 32kg.
- •With a follow-up visit at Grenoble University Hospital with a blood sampling for its care
- •Having given its written no objection to participate in the prospective phase of this project
排除标准
- •Legally protected patient (minor, pregnant or nursing woman, ward or ward curated, hospitalized under duress or deprived of liberty)
结局指标
主要结局
Isolation of recombinant human monoclonal antibodies against Pseudomonas aeruginosa
时间窗: 1 day
Detection of binding of recombinant antibodies to Pseudomonas aeruginosa target proteins by ELISA assay.
次要结局
- Isolation of functional antibodies against Pseudomonas aeruginosa(1 day)
研究者
研究点 (1)
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