NCT01761825Unknown2 期
The Effect of "Funny" Channel Blocker Ivabradine on Patients With Postural Tachycardia Syndrome.
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 入组人数
- 20
- 主要终点
- the change in heart rate after the administration of Ivabradine
研究概览
简要总结
The purpose of this study is to determine whether Ivabradine is an effective treatment for postural tachycardia syndrome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with POTS by the following criteria:
- •The presence of characteristic orthostatic symptoms of the POTS for at least six months.
- •An increase in the heart rate of at least 30 beats per minute (without concomitant significant decrease in blood pressure of more than 20/10 mmHg) within 10 minutes after assuming a standing position (or during tilt test) on at least 3 separate occasions.
- •No other concomitant diseases that could explain the symptoms of POTS.
排除标准
- •History of systemic illness capable of affecting of affecting autonomic function (eg, diabetes mellitus, SLE).
- •History of cardiovascular disease.
- •History of smoking, drug or alcohol abuse.
- •Pregnancy, and also uncontrolled thyroid or adrenal disorders.
- •Using any drug metabolized by cytochrome P450 3A4 enzyme during the last 72 hours.
研究组 & 干预措施
Ivabradine
Active Comparator
Ivabradine 10 mg once
干预措施: ivabradine (Drug)
结局指标
主要结局
the change in heart rate after the administration of Ivabradine
时间窗: 60 minutes , during the whole trial
the change in blood pressure after the administration of Ivabradine
时间窗: 60 minutes
次要结局
未报告次要终点
研究者
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