Pilot Study of Organic Nitrates on Endothelial Function in CAD Patients

Not Applicable

• Conditions: Coronary Artery Disease
• Interventions: Drug: PETN, ISDN

• Registration Number: NCT01030367
• Lead Sponsor: Julius-Maximilians University

Brief Summary

Organic nitrates increase levels of circulating endothelial progenitor cells (Thum et al., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):748-54). Here, we want to test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function.

Detailed Description

In this pilot study we test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function. These parameters will be measured before and after 14d of treatment.

Study Timeline

• Status Verified: 2007-01
• Study Start: 2007-01
• Primary Completion: 2008-11
• Study First Submitted: 2009-12-10
• Study First Submitted QC: 2009-12-10
• Last Update Submitted: 2009-12-10
• Study First Posted: 2009-12-11
• Last Update Posted: 2009-12-11
• Study Completion: 2010-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Coronary artery disease, 2- or 3-vessel disease

Exclusion Criteria

• Acute myocardial infarction, acute heart failure, cancer, acute infections

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
3	PETN, ISDN	-
1	PETN, ISDN	PETN
2	PETN, ISDN	ISDN

Primary Outcome Measures

Name	Time	Method
Endothelial function Number of endothelial progenitor cells Function of endothelial progenitor cells	Baseline and after 14d

Trial Locations

Locations (1)

Julius-Maximilians University; 🇩🇪 Würzburg, Bavaria, Germany