Pilot Study of Organic Nitrates on Endothelial Progenitor Cells and Endothelial Function in Patients With Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Endothelial function Number of endothelial progenitor cells Function of endothelial progenitor cells
研究概览
简要总结
Organic nitrates increase levels of circulating endothelial progenitor cells (Thum et al., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):748-54). Here, we want to test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function.
详细描述
In this pilot study we test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function. These parameters will be measured before and after 14d of treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Coronary artery disease, 2- or 3-vessel disease
排除标准
- •Acute myocardial infarction, acute heart failure, cancer, acute infections
研究组 & 干预措施
1
PETN
干预措施: PETN, ISDN (Drug)
2
ISDN
干预措施: PETN, ISDN (Drug)
3
干预措施: PETN, ISDN (Drug)
结局指标
主要结局
Endothelial function Number of endothelial progenitor cells Function of endothelial progenitor cells
时间窗: Baseline and after 14d
次要结局
未报告次要终点