Pilot Study of Organic Nitrates on Endothelial Progenitor Cells and Endothelial Function in Patients With Coronary Artery Disease
Overview
- Phase
- Not Applicable
- Intervention
- PETN, ISDN
- Conditions
- Coronary Artery Disease
- Sponsor
- Julius-Maximilians University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Endothelial function Number of endothelial progenitor cells Function of endothelial progenitor cells
- Last Updated
- 16 years ago
Overview
Brief Summary
Organic nitrates increase levels of circulating endothelial progenitor cells (Thum et al., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):748-54). Here, we want to test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function.
Detailed Description
In this pilot study we test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function. These parameters will be measured before and after 14d of treatment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Coronary artery disease, 2- or 3-vessel disease
Exclusion Criteria
- •Acute myocardial infarction, acute heart failure, cancer, acute infections
Arms & Interventions
1
PETN
Intervention: PETN, ISDN
2
ISDN
Intervention: PETN, ISDN
3
Intervention: PETN, ISDN
Outcomes
Primary Outcomes
Endothelial function Number of endothelial progenitor cells Function of endothelial progenitor cells
Time Frame: Baseline and after 14d