Interest of ß 1-3 D Glucan Assays in Screening for the Onset of Invasive Aspergillosis in Neutropenic Patients With Acute Leukaemia.
Not Applicable
Completed
- Conditions
- Invasive Fungal Infections
- Interventions
- Biological: blood samples
- Registration Number
- NCT02851680
- Lead Sponsor
- Centre Hospitalier Universitaire Dijon
- Brief Summary
In the context of screening for infectious fungal diseases in patients with malignant haemopathy, and particularly patients with acute leukaemia, the investigator aims to evaluate the performance of an already commercialized but little used serum screening test (Fungitell® test) and to determine its place in the management strategy for invasive aspergillosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 476
Inclusion Criteria
- Patients who have been informed about the study
- Patients over 18 years
- patients with acute myeloblastic leukaemia (AML) or lymphoblastic leukaemia (ALL) who have undergone cytotoxic chemotherapy with curative intent
Exclusion Criteria
- Adults under guardianship
- Patients without national health insurance cover
- Pregnant or breast-feeding women
- allografts and autografts of Haematopoietic Stem Cells (HSC)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fongitell test blood samples - serum galactomannan blood samples -
- Primary Outcome Measures
Name Time Method Comparison of the results of the 1-3 ß D glucan serum assay obtained with the Fungitell® test and the test currently used (in terms of specificity, sensitivity, negative predictive value and positive predictive value 8 to 10 assays over 4 to 5 weeks of hospitalization
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU Dijon Bourgogne
🇫🇷Dijon, France