WAVES (West Australian cardioVascular Events in obstructive Sleep apnoea)

Not Applicable

• Conditions: Cardiovascular disease; Obstructive Sleep Apnea; Cardiovascular - Coronary heart disease; Respiratory - Sleep apnoea

• Registration Number: ACTRN12619000699167
• Lead Sponsor: West Australian Sleep Disorders Research Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-05-09
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 1960

Inclusion Criteria

Participated in the WASHS study between 2005-2010 at the West Australian Sleep Disorders Research Institute (WASDRI)

Exclusion Criteria

Impaired capacity to consent, history of cardiovascular disease at baseline (i.e., taken during WASHs assessment between 2005-10)

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Development of incident overt CVD over 10 years <br>- defined as a composite of the following: 1) coronary artery disease – hospitalization for unstable angina, AMI, intervention (angioplasty, stent, CABG), (2) cardiac failure, (3) AF or cardioversion for AF (4) insertion of permanent pacemaker, (5) sudden cardiac death, (6) ischaemic and haemorrhagic stroke or transient ischaemic attack, and (7) CVD mortality. <br>OUTCOME ASSESSMENT: This will be assessed based on self-reported questionnaires designed specifically for this study and verified with medical practices/hospitals.<br>[10 years post original measurements (as part of WASHS study)]

Secondary Outcome Measures

Name	Time	Method
Outcomes will be evaluated against a composite measure of both sleep quality and effective treatment of sleep disordered breathing assessed via polysomnography (PSG) and download of CPAP devices.[10 years post WASHS];New onset hypertension, assessed with 24hr blood pressure readings and a self-reported questionnaire designed specifically for this study, with confirmation with GP as necessary[10 years post original data collection (WASHS)];Abnormal cardiac rhythm including abnormal heart rate variability, bradycardia, sinus pauses; assessed using ECG[10 years post WASHS];Arterial compliance assessed using Echo Doppler and OCT (Optical Coherence Tomography)[10 years post WASHS];Aortic calcification assessed using DEXA scans and CT scan for coronary artery calcium[10 years post WASHS];Cardiac pathology assessed using blood testing of CVD biomarkers (ie.., hsTn-I and NT-proBNP) <br>[10 years post WASHS]