A clinical trial to study efficacy and safety of pulsed radiofrequency as treatment of oral cancer pain.
- Conditions
- Cancer pain involving glossopharyngeal nerve in a case of oropharyngeal carcinoma with no curative intervention planned
- Registration Number
- CTRI/2016/08/007179
- Brief Summary
The Pulsed Radiofrequency (PRF) treatment has been used previously for the treatment of various pain conditions and found to be safe & effective.In this trial we will study whether PRF treatment of glossopharyngeal nerve is effective & safe in the pain management of oropharyngeal cancer patient suffering from intractable pain which can not be controlled by traditional analgesic therapy at base of tongue, tonsillar fossa, oropharynx( area supplied by glossopharyngeal nerve). PRF of glossopharyngeal nerve will be done at Operation theatre under full aseptic precaution with standard monitoring for vital signs & as day care basis. Post procedure patient will be monitored at PACU for 2 hrs and subsequently patient will be assessed at 1 week, 2week. 1 month, 2 month, 3 month post PRF at pain clinic. During their visit pain score will be noted according to numerical rating scale ( NRS). Treatment will be considered effective if there is 50% reduction in NRS at 2 week post PRF from the base line.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
Adult population (18-65 years)suffering from oropharyngeal carcinoma with no curative intervention planned( not fit for surgery) undergoing treatment by WHO step ladder II method still complaining of severe pain ( NRS>5) in the base of tongue, tonsillar fossa, pharynx- area mainly supplied by glossopharyngeal nerve.
unstable cardio-respiratory disorder coagulation & hematological disorder psychological disorder & history drug abuse non compliant for 3 months follow up injection site not suitable due to presence of infection , lymph node enlaegement bilateral involvement of glossopharyngeal nerve.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Efficacy of PRF ablation of glossopharyngeal nerve for the treatment of cancer pain by pain score by numerical rating scale Post intervention - 1week, 2 week, 1 month, 2 month, 3 month
- Secondary Outcome Measures
Name Time Method Safety profile of PRF of glossopharyngeal nerve in cancer pain during & post intervention (120 mins ) & post intervention 1 week, 2 week, 1 month, 2 month,3 month
Trial Locations
- Locations (1)
Post Graduate Institute of Medical Education & Research
🇮🇳Chandigarh, CHANDIGARH, India
Post Graduate Institute of Medical Education & Research🇮🇳Chandigarh, CHANDIGARH, IndiaDR Suryabrata ChattopadhyayPrincipal investigator08727083344drsurya24@gmail.com