Identification of Gene and Protein Markers of Kidney Injury in Aminoglycoside-treated Children
- Conditions
- InfectionRenal Dysfunction
- Interventions
- Drug: aminoglycoside
- Registration Number
- NCT00308906
- Lead Sponsor
- Virginia Commonwealth University
- Brief Summary
The purposes of this study are to identify potential gene and protein markers of aminoglycoside-induced kidney injury in infants, children and adolescents treated with aminoglycoside antibiotics.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 166
(1) Hospitalized male and female newborns, infants, children and adolescents (ages birth to 18 years) with a diagnosis of suspected or proven bacterial sepsis, meningitis or other indication necessitating aminoglycoside therapy (2) hospitalized and outpatient newborns, infants, children and adolescents (ages birth to 18 years) who are not receiving aminoglycoside therapy.
(1) Current treatment with inhaled or ophthalmic aminoglycosides (2) Prior treatment with an aminoglycoside within the last 30 days
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description 2 aminoglycoside Aminoglycoside treated infants and children without renal injury 1 aminoglycoside Hospitalized, untreated infants and children 3 aminoglycoside Aminoglycoside treated infants with renal injury
- Primary Outcome Measures
Name Time Method Indicators of renal injury Pre and post treatment
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
University of Lousiville
🇺🇸Louisville, Kentucky, United States
Virginia Commonwealth University
🇺🇸Richmond, Virginia, United States