NCT00308906已完成不适用
Assessment of Gene and Urinary Protein Expression in Aminoglycoside-treated and Untreated Infants, Children and Adolescents
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 166
- 试验地点
- 2
- 主要终点
- Indicators of renal injury
研究概览
简要总结
The purposes of this study are to identify potential gene and protein markers of aminoglycoside-induced kidney injury in infants, children and adolescents treated with aminoglycoside antibiotics.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(1) Hospitalized male and female newborns, infants, children and adolescents (ages birth to 18 years) with a diagnosis of suspected or proven bacterial sepsis, meningitis or other indication necessitating aminoglycoside therapy (2) hospitalized and outpatient newborns, infants, children and adolescents (ages birth to 18 years) who are not receiving aminoglycoside therapy.
排除标准
- •(1) Current treatment with inhaled or ophthalmic aminoglycosides (2) Prior treatment with an aminoglycoside within the last 30 days
研究组 & 干预措施
1
Hospitalized, untreated infants and children
干预措施: aminoglycoside (Drug)
2
Aminoglycoside treated infants and children without renal injury
干预措施: aminoglycoside (Drug)
3
Aminoglycoside treated infants with renal injury
干预措施: aminoglycoside (Drug)
结局指标
主要结局
Indicators of renal injury
时间窗: Pre and post treatment
次要结局
未报告次要终点
研究者
Mary Jayne Kennedy
Associate Professor
Virginia Commonwealth University
研究点 (2)
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