Corneal Stiffness and Tangent Modulus to Predict the Rate of Corneal Curvature Change in Corneal Reshaping Therapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myopia
- Sponsor
- The Hong Kong Polytechnic University
- Enrollment
- 59
- Locations
- 1
- Primary Endpoint
- Change of Corneal Stiffness From Baseline at 6 Months
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The aim of the proposed study is to investigate the predictive value of corneal biomechanical properties in corneal reshaping therapy and the role of these parameters in determining the amount of myopia reduction.
Detailed Description
Experiment 1: To evaluate changes in corneal biomechanics caused by short-term corneal reshaping therapy. Subjects will wear a conventional RGP lens in one eye, randomly selected, and an orthokeratology lens in the fellow eye, for 30 minutes, 60 minutes and one night, respectively. Corneal stiffness and tangent modulus will be measured before and after each wearing period. Experiment 2: To evaluate changes in and the recovery of corneal biomechanics effected by long-term corneal reshaping and to assess whether corneal biomechanics can predict the rate of corneal reshaping. Subjects will wear orthokeratology lenses for 6 months. Regular follow up visits (1 week, 1 month, 3 months and 6 months) will be arranged to monitor the changes in corneal stiffness and tangent modulus.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Myopia between -4D to -5D, with-the-rule astigmatism not more than 1.5D, spherical equivalent between -4D to -5.75D, difference between two eyes within 1D, best corrected spectacle visual acuity 0.10 logMAR in each eye
Exclusion Criteria
- •previous corneal reshaping therapy, long-term contact lens wear, ocular disease
Outcomes
Primary Outcomes
Change of Corneal Stiffness From Baseline at 6 Months
Time Frame: At baseline, then change from baseline to 6 months
Corneal Stiffness: in N/mm Corneal parameters usually will stabilize in 1 month, this study will monitor it till 6 months.
Secondary Outcomes
- Change of Tangent Modulus From Baseline at 6 Months(At baseline, then change from baseline to 6 months)