The Role of Adipokines Secreted by Epicardial Adipose Tissue in the Atherosclerosis of Coronary Arteries
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Association between coronary artery disease and epicardial adipokines
研究概览
简要总结
The aim of the study is to investigate whether the expression and production of adipokines secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis.
详细描述
The aim of the study is to investigate whether the expression and production of four adipokines [adiponectin, omenin-1, resistin and retinol binding protein-4 (RBP4)] secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis. Specifically, this study aims to investigate whether the expression and production of these adipokines is different between two sites of the heart, that are perfused by coronary arteries with different degrees of stenosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Individuals undergoing cardiac surgery
排除标准
- •Age < 18 years
- •HbA1c > 7.0%
- •Any change of antidiabetic medication the previous 3 months before the surgery
- •GFR < 60 mL/min/1.73 m2
- •Liver disease
- •Non-treated hyperthyroidism or hypothyroidism
- •Autoimmune disease
- •Infection
- •Any change in body weight at least 5% the previous 3 months before surgery
- •Significant dehydration.
- •Taking any of the following drugs the previous 3 months before surgery: hormones, antiobesity drugs
结局指标
主要结局
Association between coronary artery disease and epicardial adipokines
时间窗: Baseline measurement
Comparison of the mRNA and protein production of four adipokines \[adiponectin, omentin-1, resistin, retinol binding protein-4(RBP4)\] from the epicardial adipose tissue between the territories that are supplied by LAD and RCA. This comparison will be performed in the following clusters of groups: 1. Cluster 1: NonDM-0 and DM-0 (comparison between territories that are supplied by non-stenosed coronary arteries) 2. Cluster 2: NonDM-LR and DM-LR (comparison between territories that are supplied by stenosed coronary arteries) 3. Cluster 3: NonDM-L, NonDM-R, DM-L and DM-R (comparison between a territory that is supplied by stenosed coronary artery and another territory that is supplied by non-stenosed coronary artery)
次要结局
- Impact of diabetes on epicardial adipokines(Baseline measurement)
研究者
Georgios A. Christou
Cardiologist, Postdoctoral researcher
University Hospital, Ioannina