Comparison of Er:YAG and Nd:YAG efficacy in the surgical treatment of oral lichen planus based on the pre- and postoperative salivary IL-6, IL-1ß and IFN? levels

Not Applicable

• Conditions: L43.0; Hypertrophic lichen planus

• Registration Number: DRKS00020986
• Lead Sponsor: niversitätsklinikum TübingenPoliklinik für Zahnärztliche Prothetik

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-09-08
• Study Start: 2020-03-18
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 93

Inclusion Criteria

The inclusion criteria for the present study were the OLP lesions refractory to conservative therapy, which was stated after the signs of OLP did not disappear within the last 6 months.

Exclusion Criteria

The exclusion criteria were any malignance signs (n =5), presence of HIV, HBV, HSV, EBV, CMV (n = 15) and exacerbation of hypertonia and diabetes mellitus (n = 12), allergic reactions on the received conservative therapy (n = 2), pregnant female patients, or those either going to be pregnant or being in lactation period (n = 1).

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The efficacy of each treatment method was assessed basing on the inflamatory cytokines, pain and odem level reduction. <br>Based on this criteria, the Er:YAG laser type demonstrated the superior treatment outcome, followed by the combination of Er:YAG + Nd:YAG and Nd:YAG solely.

Secondary Outcome Measures

Name	Time	Method
The significant cytokine level reduction was demonstrated on the 14th and 30th day, using each type of laser, which means that the chosen inflamatory cytokines (IFNy, IL1b, IL6) are suitable for the lase effectiveness analysis.