EGD-assisted Bowel Preparation for Colonoscopy

Not Applicable

Completed

• Conditions: Colonoscopy; Esophagoscopy Techniques
• Interventions: Procedure: EGD-assisted administration of colonoscopy prep; Procedure: Control Group received standard prep by oral administration

• Registration Number: NCT01563744
• Lead Sponsor: Rockford Gastroenterology Associates

Brief Summary

Adequate bowel preparation is of critical importance for colonoscopy. Particularly among hospitalized patients, inadequate bowel preparation for colonoscopy may arise due to patient intolerance to prescribed laxative regimen, elderly population, and co-existing conditions that impair the ability to ingest a large-volume laxative regimen. Improvements in bowel preparation for colonoscopy in hospitalized patients would likely improve patient care and reduce hospital costs. The purpose of this study is to determine if administering a portion of the bowel purgative via EGD could improve colonoscopy preparation in hospitalized patients.

Detailed Description

In this randomized controlled trial in hospitalized patients, patients in whom colonoscopy was anticipated the day following EGD were consented and randomized to either standard prep by mouth (split-dose PEG) or intervention group (instillation of the first 2 liters of Nulytely solution through the channel of the endoscope into the duodenal bulb, then continue standard prep). Data is collected on quality of prep and patient satisfaction in both groups.

Study Timeline

• Study Start: 2009-08
• Primary Completion: 2012-03
• Study Completion: 2012-03
• Study First Submitted: 2012-03-23
• Study First Submitted QC: 2012-03-23
• Study First Posted: 2012-03-27
• Status Verified: 2012-04
• Last Update Submitted: 2016-04-15
• Last Update Posted: 2016-04-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

• hospitalized patients
• having EGD and expected to have colonoscopy the following day
• written informed consent

Exclusion Criteria

• unable to tolerate EGD-assisted prep administration

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
EGD-assisted colonoscopy prep	EGD-assisted administration of colonoscopy prep	2 liters of polyethylene glycol instilled through the channel of the endoscope during EGD when colonoscopy expected the following day. Patients follow a clear liquid diet, then ingest an addition 1 liter polyethylene glycol 4 hours prior to colonoscopy. Patients are also given a tap water enema 1 hour prior to colonoscopy.
Standard Colonoscopy Prep	Control Group received standard prep by oral administration	Split-dose polyethylene glycol (2 liters pm prior to colonoscopy, 1 liter 4 hours prior to colonoscopy)), clear liquid diet, metoclopramide 10 mg IV 30 minutes prior to procedure, tap water enema 1 hr prior to colonoscopy

Primary Outcome Measures

Name	Time	Method
Quality of bowel preparation	Twenty four to 48 hours - from time of consent prior to EGD until end of colonoscopy performed the following day	Quality of prep was assessed using the Ottawa bowel preparation scale (Rostom A, Jolicoeur E. Validation of a new scale for the assessment of bowel preparation quality. Gastrointest endosc 2004;59:482-6)

Secondary Outcome Measures

Name	Time	Method
Patient tolerance of bowel preparation	administered just prior to sedation for colonoscopy	Patients in both groups were asked to indicate if the bowel prep was easy, slightly difficult, moderately difficult, extremely difficult, or if they were unable to complete the prep as directed.

Trial Locations

Locations (2)

St. Anthony Medical Center; 🇺🇸 Rockford, Illinois, United States

SwedishAmerican Hospital; 🇺🇸 Rockford, Illinois, United States