MOABIT - Mechanism of Action in Bronchial Thermoplasty; A prospective single center study with a modified protocol in the endoscopic treatment of patients with severe bronchial asthma

Phase 4

• Conditions: J45.9; Asthma, unspecified

• Registration Number: DRKS00011539
• Lead Sponsor: niversität Essen Klinik für Pneumologie, Abteilung Interventionelle Pneumologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-03
• Study Completion: 2017-03-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

Severe and uncontrolled Bronchial Asthma despite of optimal medical therapy

Exclusion Criteria

Contraindication for bronchoscopy or radiofrequency.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction of airway smooth muscles in both the upper lobes 8 weeks after treatment of the main bronchi. Measurement by rEBUS and biopsy.

Secondary Outcome Measures

Name	Time	Method
Pulmonary function test (Bodyplethysmography), Quality of Life (AQLQ), paraclinical parameters (Diff-BB, FeNO, BAL) before and 12 weeks after Bronchial Thermoplasty