ltrasound guided bilateral Quadratus Lumborum Block vs intrathecal morphine for postoperative analgesia after cesarean section: a randomized controlled study

Not Applicable

Completed

• Conditions: Anaesthesia

• Registration Number: PACTR201809600342881
• Lead Sponsor: non

Brief Summary

One hundred eighteen patients were found eligible for the study. Eleven patients refused participation in the study and 17 patients met the exclusion criteria. So, ninety patients were enrolled in the study and randomized into three groups: CG (n=30), QLB (n=30), and ITM (n=30). No patient was excluded from the study thereafter due to deviation from the study protocol. The three groups were comparable regarding the baseline maternal characteristics (Table 1). IAS was significantly less with prolonged duration up to 36-h and 24-h (at rest and during movements respectively) in QBL group compared to 12-h and 6-h (at rest and during movements respectively) in ITM group (Figure 1 and 2). Total PCA morphine consumption during the first 48-h postoperatively was significantly lower in QLB group in comparison to ITM and CG group (23±10.6 mg in QBL vs 50±13.7 mg and 76±16.4 mg in ITM and CG respectively; P=0.001). Furthermore, NRS scores at rest and during movement were significantly less with QLB till 24-h and 12-h respectively compared to 6-h and 12-h respectively in ITM (Figure 3 and 4). Patients in QLB group were able to ambulate after 13.4±1.8 hours compared to 11.7±1.9 hours and 12.9±1.6 hours in the control group and the ITM group respectively with no significant difference between the three groups (p>0.05). A significantly higher number of patients suffered from pruritis in ITM group compared to control and QLB groups at 6 hours (Table 2). Moreover, incidence of mild to moderate PONV was significantly higher in ITM group (Tale 3). Most of patients in QLB were highly satisfied (93.3%) compared to less patients in CG and ITM (36.7% and 16.7% respectively) (Table 4). Sedation scale was not different among the three groups with no clinically detectable respiratory depression in any of the study patients (data not shown).

Detailed Description

Not available

Study Timeline

• Study Start: 2018-09-19
• Results First Posted: 2018-09-20
• Last Update Posted: 2023-05-29

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

After approval of the hospital ethics committee,
written informed consent was obtained from 90 ASA physical status II parturients;
between the age of 19 and 40 years
with a gestation of 37 weeks or more and normal singleton pregnancy,
scheduled for elective C.S. via a Pfannenstiel incision under spinal anesthesia

Exclusion Criteria

The exclusion criteria were as follows: history of allergy to any relevant drug,
body mass index >35 kg/m2,
coagulopathy,
chronic pain disorders,
pregnancy-induced hypertension,
gestation diabetes mellitus,
and opioids abuse.

Study & Design

• Study Type: Interventional
• Study Design: Not specified