Hot Flashes and Neurovascular Function in Women
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Compare microvascular function in women with low and high frequency hot flashes
研究概览
简要总结
Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship. As such, these studies are designed to provide a major step forward in understanding the link between hot flashes and neurovascular dysfunction and, by extension, cardiovascular disease in women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Non-smokers.
- •Non-obese.
- •Have at least one ovary.
- •Free from cardiovascular disease.
- •Not taking medications influencing cardiovascular function.
排除标准
- 未提供
研究组 & 干预措施
Experimental: Healthy Women Volunteers
Hot Flash frequency will be assessed in the study subjects during a screening period. Participants can then chose to participate 1 or 2 study visits- Protocol 1: Microvascular function and/or Protocol 2: Autonomic function
干预措施: Sodium Nitroprusside (Drug)
Experimental: Healthy Women Volunteers
Hot Flash frequency will be assessed in the study subjects during a screening period. Participants can then chose to participate 1 or 2 study visits- Protocol 1: Microvascular function and/or Protocol 2: Autonomic function
干预措施: Acetylcholine (Drug)
Experimental: Healthy Women Volunteers
Hot Flash frequency will be assessed in the study subjects during a screening period. Participants can then chose to participate 1 or 2 study visits- Protocol 1: Microvascular function and/or Protocol 2: Autonomic function
干预措施: Terbutaline (Drug)
Experimental: Healthy Women Volunteers
Hot Flash frequency will be assessed in the study subjects during a screening period. Participants can then chose to participate 1 or 2 study visits- Protocol 1: Microvascular function and/or Protocol 2: Autonomic function
干预措施: Norepinephrine (Drug)
Experimental: Healthy Women Volunteers
Hot Flash frequency will be assessed in the study subjects during a screening period. Participants can then chose to participate 1 or 2 study visits- Protocol 1: Microvascular function and/or Protocol 2: Autonomic function
干预措施: Sympathoexcitatory stressors (Other)
结局指标
主要结局
Compare microvascular function in women with low and high frequency hot flashes
时间窗: Continuous measurement of vascular conductance during infusion of each drug- 3min at baseline and at each drug dose (~60min total of continuous forearm vascular conductance measurements)
Change in forearm vascular conductance with intra-arterial drug infusions. Vascular conductance is an index of vascular tone and is assessed using a technique called venous occlusion plethysmography
Compare sympathetic function in women with low and high frequency hot flashes
时间窗: Continuous measurement of muscle sympathetic nerve activity at rest and in response to stressors (~75min of continuous data collection once a sympathetic nerve signal is found)
Muscle Sympathetic Nerve Activity will be directly using a technique called microneurography.
次要结局
未报告次要终点
研究者
Sarah E. Baker, Ph.D.
Principal Investigator
Mayo Clinic