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The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

Not Applicable
Completed
Conditions
Ischemia
Interventions
Registration Number
NCT02756715
Lead Sponsor
Konkuk University Medical Center
Brief Summary

Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.

The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.

Detailed Description

The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.

1. Preoperation (immediate before anesthesia induction)

2. Immediate before tourniquet off

3. 5 min after tourniquet off

4. PACU

5. postoperative 6 hours

6. postoperative 24 hours

Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
80
Inclusion Criteria
  • patients who was planned to undergo knee surgery.
Exclusion Criteria
  • age < 20 years old
  • history of previous cancer
  • history of previous peripheral vascular disease
  • Emergency surgery

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
propofol grouppropofol groupThe patient who anesthetized by using propofol.
Desflurane groupDesflurane groupThe patient who anesthetized by using sevoflurane.
Primary Outcome Measures
NameTimeMethod
Syndecan-1Preoperative time, Immediate before tourniquet off,5 min after tourniquet off,PACU, postoperation after 6hours, postoperation after 24hours

change of level of syndecan-1 (scores range from 0 to 100)

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Konkuk University Medical Center

🇰🇷

Seoul, Korea, Republic of

Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of

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