The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Syndecan-1
Study Overview
Brief Summary
Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.
The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.
Detailed Description
The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.
- Preoperation (immediate before anesthesia induction)
- Immediate before tourniquet off
- 5 min after tourniquet off
- PACU
- postoperative 6 hours
- postoperative 24 hours
Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 20 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients who was planned to undergo knee surgery.
Exclusion Criteria
- •age < 20 years old
- •history of previous cancer
- •history of previous peripheral vascular disease
- •Emergency surgery
Arms & Interventions
propofol group
The patient who anesthetized by using propofol.
Intervention: propofol group (Drug)
Desflurane group
The patient who anesthetized by using sevoflurane.
Intervention: Desflurane group (Drug)
Outcomes
Primary Outcomes
Syndecan-1
Time Frame: Preoperative time, Immediate before tourniquet off,5 min after tourniquet off,PACU, postoperation after 6hours, postoperation after 24hours
change of level of syndecan-1 (scores range from 0 to 100)
Secondary Outcomes
No secondary outcomes reported
Investigators
Seong-Hyop Kim
Associate Professor
Konkuk University Medical Center