The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery
- Registration Number
- NCT02756715
- Lead Sponsor
- Konkuk University Medical Center
- Brief Summary
Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.
The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.
- Detailed Description
The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.
1. Preoperation (immediate before anesthesia induction)
2. Immediate before tourniquet off
3. 5 min after tourniquet off
4. PACU
5. postoperative 6 hours
6. postoperative 24 hours
Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
- patients who was planned to undergo knee surgery.
- age < 20 years old
- history of previous cancer
- history of previous peripheral vascular disease
- Emergency surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description propofol group propofol group The patient who anesthetized by using propofol. Desflurane group Desflurane group The patient who anesthetized by using sevoflurane.
- Primary Outcome Measures
Name Time Method Syndecan-1 Preoperative time, Immediate before tourniquet off,5 min after tourniquet off,PACU, postoperation after 6hours, postoperation after 24hours change of level of syndecan-1 (scores range from 0 to 100)
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (1)
Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of
Konkuk University Medical Center🇰🇷Seoul, Korea, Republic of