Circulating Tumor DNA in Patients With Colorectal Cancer Undergoing Curative-intent Surgery for Liver Metastases: Prospective, Multicenter, GERCOR Cohort
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Metastatic Colorectal Cancer
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
- Enrollment
- 232
- Locations
- 16
- Primary Endpoint
- Disease-free survival (DFS) in patients who undergo curative-intent resection of colorectal liver metastasis (CRLM)
- Status
- Recruiting
- Last Updated
- 9 months ago
Overview
Brief Summary
This is a prospective multicenter cohort study, was designed to explore the prognostic value of ctDNA as a biomarker of disease response and recurrence or death in patients undergoing curative-intent surgical resection of Colorectal cancer liver metastasis.
Detailed Description
Blood collection times according to specific clinical situations: * Standard approach * Combined surgery * Reverse strategy * Two-stage hepatectomy
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Disease-free survival (DFS) in patients who undergo curative-intent resection of colorectal liver metastasis (CRLM)
Time Frame: Up to 36 months
DFS is defined as the time from complete surgical resection (following first surgery if one-stage surgery or second surgery if two-stage strategy) to first documented event (relapse or death, whichever occurred first), or until last contact if no event occurs.
Secondary Outcomes
- Prognostic factor(s) for disease recurrence and survival.(Up to 4 years)
- Number of event-free survival (EFS) in patients who undergo curative-intent resection of CRLM.(Up to 4 years)
- Overall survival (OS) n patients who undergo curative-intent resection of CRLM.(Up to 4 years)
- Prognostic value of ctDNA(Up to 4 years)
- Association between ctDNA and clinical features.(Up to 4 years)
- Time to surgical failure (TSF) in patients who undergo curative-intent resection of CRLM.(Up to 4 years)