Evaluation of Serum Sestrin Levels in Patients With Leiomyoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 61
- 试验地点
- 1
- 主要终点
- Evaluating the role of autophagia in the development of leiomyomas by evaluating the serum sestrin levels.
研究概览
简要总结
Leiomyomas are the most common benign neoplasms of women's reproductive system affecting 20-30% of women within the reproductive ages. Sestrins are serum proteins which are highly expressed under circumstances of DNA damage, hypoxia and oxditive stress and play an important role in autophagia. The aim of this study is to evaluate the relationship of serum sestrin proteins with development of leiomyomas.
详细描述
Leiomyomas are the benign neoplasms of uterus and the role of genetics, estrogen levels and obesity has already been shown in their development. Higher levels of serum sestrin proteins have already been associated with DNA damage, hypoxia and oxidative stress and sestrin plays an important role in autophagia. In order to evaluate the role of serum sestrin in the development of leiomyomas 30 patients between 18-45 years of age who were diagnosed with uterine leiomyomas with transvaginal ultrasonography will be included in the study group. Their serum sestrin levels will be determined and compared with that of 30 healthy subjects recruited during the same study period at the same clinic.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •18-45 years of age
- •patients diagnosed with uterine leiomyomas will be included in the study group
- •patients without any additional comorbidities
- •patients without any autoimmune diseases
排除标准
- •patients with systemic diseases
- •patients with known chronic inflammatory diseases
- •patients using hormonal and/or medical therapy
- •pregnant women
- •lactating women
- •patients with malignant diseases
结局指标
主要结局
Evaluating the role of autophagia in the development of leiomyomas by evaluating the serum sestrin levels.
时间窗: 2 months
Increased levels of serum sestrin proteins are associated with impaired autophagia. This association will be evaluated in the context of leiomyoma patients by measuring serum sestrin levels in blood samples obtained from these patients and comparing them with the sestrin levels measured in healthy subjects.
次要结局
未报告次要终点
研究者
Nura Fitnat Topbas Selcuki
MD, Specialist in Obstetrics and Gynecology
Sisli Hamidiye Etfal Training and Research Hospital