Relationship between peak temperature and survival of neutropenic sepsis in intensive care

Not Applicable

Completed

• Conditions: eutropenic sepsis; Febrile neutropenia; Haematological malignancy; Neutropenic sepsis; Infection - Other infectious diseases; Cancer - Any cancer; Blood - Other blood disorders

• Registration Number: ACTRN12613000784718
• Lead Sponsor: Dr Robert Weinkove

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-07-15
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 10000

Inclusion Criteria

All patients admitted to an adult ICU at one of 157 centres in Australia and New Zealand between 2005 and 2013 for whom information is available on the Australian and New Zealand Intensive Care Society (ANZICS) Adult Patient Database (APD).

Neutropenic sepsis cohort:
White cell count equal to or less than 1.0 x10^9/L within the first 24 hours on the intensive care unit
APACHE-II diagnostic code indicating infection or haematological malignancy

Neutropenic sepsis with haematological malignancy cohort:
White cell count equal to or less than 1.0 x10^9/L within the first 24 hours on the intensive care unit
APACHE-II diagnostic or comorbidity code indicating haematological malignancy

Non-neutropenic sepsis cohort:
White cell count greater than or equal to 4.0 x10^9/L during the first 24 hours on the intensive care unit
APACHE-II diagnostic code indicating infection

Exclusion Criteria

No recorded white cell count during first 24 hours on intensive care unit
No recorded temperature during first 24 hours on intensive care unit

For Non-neutropenic sepsis cohort only:
APACHE-II diagnostic code or comorbidity code indicating a haematological malignancy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In-hospital mortality, adjusted for illness severity by APACHE III risk of death (excluding temperature), and classified according to peak documented temperature during the first 24 hours following admission to the intensive care unit.[During inpatient episode. No censoring is applied. Patients for whom inpatient survival data are not available at the time of analysis will be excluded.]

Secondary Outcome Measures

Name	Time	Method
ICU length of stay, adjusted for illness severity by APACHE III risk of death (excluding temperature)[During inpatient episode. No censoring is applied. Patients for whom inpatient survival data are not available at the time of analysis will be excluded.]