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临床试验/NCT04312425
NCT04312425已完成不适用

Comparison of Classic and Modified Rapid Sequence Induction on Prevention of Perioperative Gastric Content Regurgitation in Emergency Surgery Under General Anesthesia

The First Affiliated Hospital with Nanjing Medical University1 个研究点 分布在 1 个国家目标入组 8,601 人开始时间: 2020年3月5日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
8,601
试验地点
1
主要终点
Incidence of gastric content regurgitation

研究概览

简要总结

Induction of anesthesia induces a loss of protective upper airway reflexes and is associated with gastric content regurgitation. Emergency surgery bears a higher risk of gastric content regurgitation because of full stomach, delayed gastric emptying, intestinal obstruction, stroke or other factors. Rapid sequence induction (RSI) of anesthesia was recommended to minimize the risk of regurgitation and aspiration. Classic RSI scheme mainly includes the use of short-acting sedatives and muscle relaxant, together with a manual pressure to the cricoid cartilage (Sellick maneuver) which aims at compressing the esophagus to avoid regurgitation. Though widely recommended, the scheme has been controversial for years. Our department modified the scheme and put it into use in day shift emergency surgery since March 1, 2018. This retrospective analysis is aimed at comparing the effect of classic and modified rapid sequence induction in prevention of gastric content regurgitation in emergency surgery under general anesthesia.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Patients receive emergency surgery under general anesthesia March 1, 2015 to February 29, 2020
  • •Eighteen years or older

排除标准

  • •Trachea intubation status on admission
  • •Tracheotomy
  • •Bronchoscope surgery
  • •General anesthesia with laryngeal mask
  • •Awake intubation

结局指标

主要结局

Incidence of gastric content regurgitation

时间窗: From entering operation room to endotracheal intubation completed.

The Electronic Anesthesia Record System files contained the word "aspiration" and/or "gastric content" were extracted and carefully evaluated. The events of gastric content regurgitation on admission or observed during tracheal intubation were recorded and analyzed.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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