The noradrenergic basis of Parkinson’s tremor: a systems-level fMRI approach

Radboud University Nijmegen0 个研究点目标入组 64 人开始时间: 2021年12月10日最近更新: 2023年9月4日

适应症

试验速览

暂无简介。

•1. Idiopathic Parkinson’s disease according to UK brain bank criteria
•2. Age range: 18-80 years
•3. Tremor-dominant group: the presence of clear resting tremor for at least one arm (defined as a resting tremor score of =2 MDS-UPDRS points)
•4. Non-tremor group: absence of clear resting and postural tremor

•1. Neuropsychiatric co-morbidity
•2. Contraindications for MRI scanning (e.g. pacemaker, implanted metal parts, deep brain stimulation, claustrophobia)
•3. Cardiac arrhythmias (in patient history or visible on ECG)
•4. Contraindications for beta-blockers (e.g. bradycardia, peripheral circulation disturbances, asthma or obstructive lung disease, hypotension)
•5. Use of medication that may interact with propranolol
•6. Use of medication that inhibits relevant CYP enzymes that are involved in metabolizing propranolol
•7. Severe head tremor or dyskinesias
•8. Cognitive impairment (Mini-Mental State Exam [MMSE] <26)
•9. Parkinson disease duration >10 years, severe ON/OFF medication fluctuations, or daily Levodopa-equivalent dose >1200 mg

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