Wake-sleep Cycle and Melatonin Secretion Dynamics Associated With 12 Hours Shift Work in French Nurses
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- total amount of melatonin excreted during the sleep period for the night shift
Study Overview
Brief Summary
Nonstandard time-schedules work are widespread in the world of work. Shift and night work have been shown to be responsible for a desynchronization of biological rhythms, associated with melatonin secretion impairment and sleep disturbances. However, while health consequences of night and shift work are widely recognized and represent a major public health concern (High Authority of Health 2012 Recommendations and National Agency for Public Health Food, Environment and Work 2016 Report), the mechanisms by which the circadian system is affected by shift work remain poorly understood. Indeed most of the studies in the fields are cross-sectional, based on few blood or urinary samples in a single work position, in workers whose shift work patterns are often misidentified and heterogeneous. Moreover, few studies have assessed melatonin secretion alterations in relation to objective sleep measurement (actigraphy). The aim of this study is to assess the dynamics of melatonin secretion adaptation in 12-hour shift work and to correlate these data to sleep-wake cycle recording.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Nurses or nursing assistants working in the Sleep and Respiratory Diseases Department of the Croix-Rousse Hospital with positions in 12 hours for more than 6 months
- •informed consent given by the subject
Exclusion Criteria
- •Pregnancy or lactation <6 months
- •Taking treatment modifying the secretion of melatonin (melatoninergic drugs (including antidepressants), beta-blockers)
- •Refusal of participate
- •Minor or major protected subject
- •Not affiliated to a social security scheme
- •Participant in another interventional study interfering with sleep / wake rhythm or work schedules (judgment of the investigator)
Arms & Interventions
melatonin and cortisol sampling
14 healthy volunteer nurses working on 12 hours night/day schedules in the Sleep Medicine Center of Lyon.
Intervention: melatonin and cortisol sampling (Other)
Outcomes
Primary Outcomes
total amount of melatonin excreted during the sleep period for the night shift
Time Frame: at day 8 (night shift)
The impact of 12H shift work on melatonin secretion dynamics will be assessed by comparing the total amount of melatonin excreted during the sleep period between the 12h day shift condition and the 12h night shift condition
total amount of melatonin excreted during the sleep period for the day shift.
Time Frame: at day 2 (day shift)
The impact of 12H shift work on melatonin secretion dynamics will be assessed by comparing the total amount of melatonin excreted during the sleep period between the 12h day shift condition and the 12h night shift condition
Secondary Outcomes
- Cortisol secretion dynamics in 12h day shift(at day 2 (day shift))
- Cortisol secretion dynamics in 12h night shift(at day 8 (night shift))
- Cortisol secretion dynamics at rest(at day 13 (rest))
- Objective sleep quality(15 days)
- Melatonin secretion dynamics in 12h day shift(at day 2 (day shift))
- Melatonin secretion dynamics in 12h night shift(at day 8 (night shift))
- Melatonin secretion dynamics at rest(at day 13 (rest))
- Insomnia severity(at day 1)
- Chronotype(at day 1)
- Sleep subjective quality(at day 2, 8 and 13)
- Light exposition(15 days)
- Total amount of melatonin excreted during the sleep period at rest(at day 13 (rest))
- Asthenia(at day 1)
- Objective sleep duration(15 days)
- Excessive daytime sleepiness(at day 1)
- Anxiety(at day 1)
- Depression(at day 1)
- Vigilance at awakening(at day 2, 8 and 13)