ACTRN12605000170628
Terminated
Phase 4
A placebo controlled study to test the effectiveness of atorvastatin and irbesartan on infarct size, cerebral perfusion, cerebral response to ischaemia and clinical outcome in acute ischaemic stroke
niversity of Western Australia0 sites200 target enrollmentAugust 17, 2005
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Acute Ischaemic Stroke
- Sponsor
- niversity of Western Australia
- Enrollment
- 200
- Status
- Terminated
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All patients admitted within 72 hours of onset of symptoms will be eligible for trial entry, unless exclusion criteria are met.If a person is unable to provide informed consent the next of kin will be sought to provide consent. Patients regaining capacity will be free to continue in or withdraw from the trial.
Exclusion Criteria
- •Hypotension: Blood pressure less than 100mmHg systolic or 70mmHg diastolic. Hypertension (\>220 mmHg) or clinical imperative to lower blood pressure. Hyperkalaemia: \>5\.5 mmol/L. Finger prick or laboratory blood sugar level \> 13 mmol/L at baseline. Acute comorbid condition (such as myocardial ischaemia or sepsis). Active liver disease or unexplained elevation in transaminases. Already treated with ATRA, statin or more than one of an ACE inhibitor, non steroidal anti\-inflammatory, potassium sparing diuretic, potassium salt or cyclosporin. Premenopausal female. Renal impairment (defined as creatinine \>120 umol/L). History of sensitivity to statins, ATRA or contrast. Haemorrhage seen on initial CT.
Outcomes
Primary Outcomes
Not specified
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