Visualization of nerves and muscles in the forearm - In patients with multifocal motor neuropathy (MMN), amyotrophic lateral sclerosis (ALS), and healthy volunteers - VISA study

niversitair Medisch Centrum0 个研究点目标入组 30 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•Patients with MMN
•* Slowly progressive or stepwise progressive limb weakness
•* Asymmetrical limb weakness
•* Number of affected limb regions < 7. Limb regions are defined as upper arm, lower arm, upper leg, or lower leg on both sides
•* Decreased or absent tendon reflexes in affected limbs
•* Signs and symptoms are more pronounced in upper limbs than in lower limbs
•* Age at onset of disease: 20*65 years;Patients with ALS
•Inclusion criteria are based on the guidelines for diagnosis explained by [18]
•* Evidence of lower motor neuron degeneration by clinical, electrophysiological or neuropathological examination
•* Evidence of upper motor neuron degeneration by clinical examination
•* Progressive spread of symptoms or signs within a region or to other regions, as determined by history or examination
•* Patient should be between 20-65 years;Healthy controls
•* Volunteers are healthy
•* Volunteers are 18 year or older
•* Volunteers are capable and prepared to sign an informed consent form

•Patients with MMN
•* The patients should have no objective sensory abnormalities except for vibration sense
•* The patients should have no bulbar signs or symptoms
•* The patients should have no upper motor neuron features
•* The patients should have no other neuropathies (eg, diabetic, lead, porphyric or vasculitic neuropathy; chronic inflammatory demyelinating polyneuropathy; Lyme neuroborreliosis; postradiation neuropathy; hereditary neuropathy with liability to pressure palsies; Charcot-Marie-Tooth neuropathies; meningeal carcinomatosis)
•* The patients should have no myopathy (eg, facioscapulohumeral muscular dystrophy, inclusion body myositis);Patients with ALS
•* Patients should not have other disease processes that might explain the signs of lower/upper motor neuron degeneration
•* The patients should have no other neuropathies (eg, diabetic, lead, porphyric or vasculitic neuropathy; chronic inflammatory demyelinating polyneuropathy; Lyme neuroborreliosis; postradiation neuropathy; hereditary neuropathy with liability to pressure palsies; Charcot-Marie-Tooth neuropathies; meningeal carcinomatosis)
•* The patients should have no myopathy (eg, facioscapulohumeral muscular dystrophy, inclusion body myositis);Healthy controls
•* Volunteers with contra-indications for MRI (like a pacemaker, claustrophobia).
•* Volunteers with known MMN, ALS or other neuropathy related disease

发起方

niversitair Medisch Centrum